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粪便微生物群移植捐赠者的经历与态度:一项来自中国的实证性生物伦理学研究。

Donors' experiences and attitudes of fecal microbiota transplantation: An empirical bioethics study from China.

作者信息

Ma Yonghui, Ke Dawei, Li Danyi, Zhang Quan

机构信息

Medical Humanities and Bioethics Center, School of Medicine Xiamen University Xiamen China.

R Institute Co. Ltd. Beijing China.

出版信息

Imeta. 2022 Nov 21;1(4):e62. doi: 10.1002/imt2.62. eCollection 2022 Dec.

DOI:10.1002/imt2.62
PMID:38867907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10989884/
Abstract

Donor participation is a critical part of ensuring the development of human microbiome research and the clinical application of fecal microbiota transplantation (FMT). Most FMT donors are still not sufficiently aware of the risks associated with the act of donating gut microbiota, especially the risk of data privacy disclosure. Enhanced awareness of the moral responsibility of the researchers and ethical oversight by ethics committees are needed.

摘要

供体参与是确保人类微生物组研究发展和粪便微生物群移植(FMT)临床应用的关键部分。大多数FMT供体仍未充分意识到捐赠肠道微生物群行为所带来的风险,尤其是数据隐私泄露的风险。需要提高研究人员的道德责任感,并加强伦理委员会的伦理监督。

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本文引用的文献

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Front Cell Infect Microbiol. 2021 Apr 15;11:622949. doi: 10.3389/fcimb.2021.622949. eCollection 2021.
2
Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor.粪便微生物群移植:筛选与选择以挑选最佳供体
J Clin Med. 2020 Jun 5;9(6):1757. doi: 10.3390/jcm9061757.
3
FMT and Microbial Medical Products: Generating High-Quality Evidence through Good Governance.粪菌移植与微生物医疗产品:通过良好治理产生高质量证据。
J Law Med Ethics. 2019 Dec;47(4):505-523. doi: 10.1177/1073110519897727.
4
The Impact of Regulatory Policies on the Future of Fecal Microbiota Transplantation.监管政策对粪便微生物群移植未来的影响。
J Law Med Ethics. 2019 Dec;47(4):482-504. doi: 10.1177/1073110519897726.
5
Ethical implications of recruiting universal stool donors for faecal microbiota transplantation.招募通用粪便供体进行粪便微生物群移植的伦理问题。
Lancet Infect Dis. 2020 Mar;20(3):e44-e49. doi: 10.1016/S1473-3099(19)30569-9. Epub 2019 Nov 26.
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The Super-Donor Phenomenon in Fecal Microbiota Transplantation.粪便微生物移植中的超级供体现象。
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