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高盐饮食通过肠道微生物群和丁酸盐诱导小鼠突触丧失和记忆障碍。

A high-salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice.

作者信息

Lei Chao, Liu Cong, Peng Yuling, Zhan Yu, Zhang Xiaoming, Liu Ting, Liu Zhihua

机构信息

Department of Anorectal Surgery, Affiliated Dongguan Hospital Southern Medical University (Dongguan People's Hospital) Dongguan China.

Innovation Centre for Advanced Interdisciplinary Medicine, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou China.

出版信息

Imeta. 2023 Mar 21;2(2):e97. doi: 10.1002/imt2.97. eCollection 2023 May.

DOI:10.1002/imt2.97
PMID:38868427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10989808/
Abstract

High-salt diet (HSD)-fed mice display cognitive impairment and lower synaptic proteins via changed gut microbiota composition and short-chain fatty acids production. Gut microbiota from HSD-fed mice impairs memory and synapse in normal salt diet-fed mice. Butyrate treatment partially reverses memory impairment in HSD-fed mice. Above all, this study indicates the important role of the gut microbiome and butyrate production in synaptic loss and memory impairment.

摘要

喂食高盐饮食（HSD）的小鼠通过改变肠道微生物群组成和短链脂肪酸生成，表现出认知障碍和较低的突触蛋白水平。来自喂食HSD小鼠的肠道微生物群会损害正常盐饮食喂养小鼠的记忆和突触。丁酸盐治疗可部分逆转喂食HSD小鼠的记忆障碍。最重要的是，这项研究表明肠道微生物群和丁酸盐生成在突触丧失和记忆障碍中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/0f2979576386/IMT2-2-e97-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/c92adfce5cf3/IMT2-2-e97-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/1db66dd46bb4/IMT2-2-e97-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/0f2979576386/IMT2-2-e97-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/c92adfce5cf3/IMT2-2-e97-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/1db66dd46bb4/IMT2-2-e97-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fbf/10989808/0f2979576386/IMT2-2-e97-g003.jpg

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