Clin Lab. 2024 Jun 1;70(6). doi: 10.7754/Clin.Lab.2024.240122.
TSH and ACTH are crucial hormones for diagnosing thyroid and adrenal diseases, and incorrect test reports can cause significant harm to patients.
The TSH and ACTH levels on the testing system of our laboratory were measured using "sandwich" assays. The patient had heterophilic antibodies in their body, causing a false increase in TSH and ACTH levels.
TSH on the Abbott platform was 59.7 μIU/mL and on the Roche platform it was 4.33 μIU/mL. After pretreatment with HBR it was 3.95 μIU/mL; ACTH on the SIEMENS platform was 263.5 pg/mL, on the Abbott platform it was 47.6 pg/mL. After pretreatment with HBR it was 36.5 pg/mL.
The patient's serum contains heterophilic antibodies, which interfere with the TSH and ACTH tested by this method.
TSH 和 ACTH 是诊断甲状腺和肾上腺疾病的关键激素，不正确的检测报告可能会对患者造成严重的危害。
本实验室检测系统采用“夹心”法检测 TSH 和 ACTH 水平。患者体内存在异嗜性抗体，导致 TSH 和 ACTH 水平假性升高。
雅培平台 TSH 为 59.7 μIU/mL，罗氏平台 TSH 为 4.33 μIU/mL。经过 HBR 预处理后 TSH 为 3.95 μIU/mL；西门子平台 ACTH 为 263.5 pg/mL，雅培平台 ACTH 为 47.6 pg/mL。经过 HBR 预处理后 ACTH 为 36.5 pg/mL。
患者血清中含有异嗜性抗体，干扰了该方法检测的 TSH 和 ACTH。
