Zhang Yuna, Xue Cuili, Xu Yuli, Cui Shengsheng, Ganeev Alexander A, Kistenev Yury V, Gubal Anna, Chuchina Victoria, Jin Han, Cui Daxiang
Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240 China.
St Petersburg University, 7/9 Universitetskaya Emb., St Petersburg, 199034 Russia.
Nano Res. 2023;16(2):2968-2979. doi: 10.1007/s12274-022-4914-1. Epub 2022 Sep 3.
Metal-organic frameworks (MOFs) have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties. Besides, surface-enhanced Raman scattering (SERS) technology has also rapidly developed into a powerful fingerprint spectroscopic technique that can provide rapid, non-invasive, non-destructive, and ultra-sensitive detection, even down to single molecular level. Consequently, a considerable amount of researchers combined MOFs with the SERS technique to further improve the sensing performance and broaden the applications of SERS substrates. Herein, representative synthesis strategies of MOFs to fabricate SERS-active substrates are summarized and their applications in ultra-sensitive biomedical trace detection are also reviewed. Besides, relative barriers, advantages, disadvantages, future trends, and prospects are particularly discussed to give guidance to relevant researchers.
金属有机框架材料（MOFs）因其在微观结构和性能方面独特且前所未有的优势而引起了广泛关注。此外，表面增强拉曼散射（SERS）技术也迅速发展成为一种强大的指纹光谱技术，能够提供快速、非侵入性、非破坏性以及超灵敏的检测，甚至可达单分子水平。因此，大量研究人员将MOFs与SERS技术相结合，以进一步提高传感性能并拓宽SERS基底的应用范围。在此，总结了用于制备SERS活性基底的MOFs的代表性合成策略，并对其在超灵敏生物医学痕量检测中的应用进行了综述。此外，还特别讨论了相关障碍、优点、缺点、未来趋势和前景，以为相关研究人员提供指导。
