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用于生物传感器的荧光碳点和石墨烯量子点的最新进展:溶液法合成及其医学应用

Recent Progress of Fluorescent Carbon Dots and Graphene Quantum Dots for Biosensors: Synthesis of Solution Methods and their Medical Applications.

作者信息

Khan Rafaqat, Qureshi Amina, Azhar Muhammad, Hassan Zia Ul, Gul Sagheer, Ahmad Saeed

机构信息

Department of Chemistry, Government Postgraduate College, Manshera, 21300, Pakistan.

Department of Physics, Government Postgraduate College, Manshera, 21300, Pakistan.

出版信息

J Fluoresc. 2025 May;35(5):2623-2640. doi: 10.1007/s10895-024-03809-3. Epub 2024 Jun 13.

Abstract

In the fields of health and biology, fluorescent nanomaterials have emerged as highly potential and very useful candidates for use in biosensor applications. These typical highly powerful nanomaterials are carbon dots (CDs) and graphene quantum dots (GQDs) among many other metallic nanomaterials. In the context of medical biosensors, this review article investigates the techniques of synthesis, and many uses of these nanomaterials, the obstacles that they face, and the potential for their future. We cover the significance of fluorescent nanomaterials, their use in the medical field, as well as the several techniques of synthesis for CDs and GQDs, including ultrasonication, hydrothermal, electrochemical method, surface modification, and solvothermal. In addition, we also discuss their biomedical applications, which include biomolecule detection, disease diagnosis and examine the obstacles and prospective possibilities for development of ultra-bright, ultra-sensitive, and selective biosensors for use in in-vivo research.Fluorescent carbon dots and graphene quantum dots is synthesized by using several types of raw material and methods. These Carbon dots and graphene quantum dots are used in the medical field includes detection of biomaterials, detection of cancer, virus and mutation in DNA.

摘要

在健康与生物学领域,荧光纳米材料已成为生物传感器应用中极具潜力且非常有用的候选材料。在众多其他金属纳米材料中,这些典型的高性能纳米材料包括碳点(CDs)和石墨烯量子点(GQDs)。在医用生物传感器的背景下,这篇综述文章研究了这些纳米材料的合成技术、多种用途、面临的障碍以及未来的潜力。我们涵盖了荧光纳米材料的重要性、它们在医学领域的应用,以及碳点和石墨烯量子点的几种合成技术,包括超声处理、水热法、电化学方法、表面改性和溶剂热法。此外,我们还讨论了它们的生物医学应用,包括生物分子检测、疾病诊断,并审视了用于体内研究的超亮、超灵敏和选择性生物传感器开发所面临的障碍和未来可能的发展。荧光碳点和石墨烯量子点是通过使用多种类型的原材料和方法合成的。这些碳点和石墨烯量子点在医学领域的应用包括生物材料检测、癌症检测、病毒检测以及DNA突变检测。

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