Huang H, Fan Y, Yan F, Hu Y, He H, Xu T, Zhu X, Zhu Y, Diao W, Xia X, Tu J, Li A, Lin B, Liu Q, Lu Z, Xi T, Wang W, Xu D, Chen Z, Wang Z, Chen X, Shan G
Department of Epidemiology and Statistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical College, Beijing, China.
State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China.
J Endocrinol Invest. 2025 Jan;48(1):233-243. doi: 10.1007/s40618-024-02406-2. Epub 2024 Jun 13.
To examine the effect of diabetes, duration of diabetes, and blood glucose on speech-, low/mid-, and high-frequency hearing loss.
In this cross-sectional study, 2821 participants aged 20-87 years in the China National Health Survey were included. Diabetes was defined as valid fasting blood glucose (FBG) of ≥ 7.0 mmol/L, a self-reported history of diabetes or the use of anti-diabetic medications. Speech-(500, 1000, 2000, and 4000 Hz), low/mid- (500, 1000 and 2000 Hz), and high-frequency (4000, 6000, and 8000 Hz) hearing loss was defined as pure tone average of responding frequencies > 20 dB HL in the better ear, respectively.
In fully adjusted models, for speech-, low/mid-, and high-frequency hearing loss, compared with no diabetes, those with diabetes (OR[95%CI]: 1.44 [1.12, 1.86], 1.23 [0.94, 1.61], and 1.75 [1.28, 2.41], respectively) and with diabetes for > 5 years duration (OR[95%CI]: 1.63 [1.09, 2.42], and 1.63 [1.12, 2.36], 2.15 [1.25, 3.70], respectively) were at higher risk. High FBG level was associated with a higher risk of speech-, low/ mid-, and high-frequency hearing loss. And there were stronger associations between HL and diabetes, longer duration and higher in "healthier population" (no hypertension, no dyslipidemia and younger age).
Diabetes, longer duration, and higher FBG level were independently associated with hearing loss for speech-, low/mid- and high-frequency hearing loss, particularly in higher frequency and "healthier population". Paying more attention to hearing loss in those populations could lower the burden of hearing loss.
研究糖尿病、糖尿病病程及血糖对言语频率、低/中频和高频听力损失的影响。
在这项横断面研究中，纳入了中国国家健康调查中2821名年龄在20 - 87岁的参与者。糖尿病定义为空腹血糖（FBG）≥7.0 mmol/L、自我报告的糖尿病病史或使用抗糖尿病药物。言语频率（500、1000、2000和4000 Hz）、低/中频（500、1000和2000 Hz）和高频（4000、6000和8000 Hz）听力损失分别定义为较好耳相应频率的纯音平均听阈>20 dB HL。
在完全调整模型中，对于言语频率、低/中频和高频听力损失，与无糖尿病者相比，糖尿病患者（OR[95%CI]：分别为1.44[1.12, 1.86]、1.23[0.94, 1.61]和1.75[1.28, 2.41]）以及糖尿病病程>5年者（OR[95%CI]：分别为1.63[1.09, 2.42]、1.63[1.12, 2.36]和2.15[1.25, 3.70]）的风险更高。高血糖水平与言语频率、低/中频和高频听力损失的风险更高相关。并且在“健康人群”（无高血压、无血脂异常且年龄较小）中，听力损失与糖尿病、病程较长和血糖较高之间的关联更强。
糖尿病、较长病程和较高血糖水平与言语频率、低/中频和高频听力损失独立相关，尤其是在高频和“健康人群”中。对这些人群的听力损失给予更多关注可降低听力损失负担。
