神经纤毛蛋白将呼肠孤病毒邀请进入神经元。

Neuropilin invites reoviruses into neurons.

机构信息

Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.

出版信息

Cell Host Microbe. 2024 Jun 12;32(6):945-946. doi: 10.1016/j.chom.2024.05.013.

DOI:10.1016/j.chom.2024.05.013

Abstract

In this issue of Cell Host & Microbe, Shang et al. identify murine neuropilin 1 as a host factor that binds reovirus particles, directing cell entry and contributing to viral dissemination and neurovirulence. This study highlights the reovirus model system to investigate host receptors and their significance in viral pathogenesis.

摘要

在本期《细胞宿主与微生物》中，Shang 等人鉴定了小鼠神经纤毛蛋白 1 是一种宿主因子，可与呼肠孤病毒颗粒结合，指导细胞进入并有助于病毒传播和神经毒力。这项研究强调了呼肠孤病毒模型系统，以研究宿主受体及其在病毒发病机制中的意义。