Huaqiao University Hospital, Quanzhou, Fujian, 362021, China.
Quanzhou First Hospital, Quanzhou, Fujian, 362000, China.
Microb Pathog. 2024 Aug;193:106741. doi: 10.1016/j.micpath.2024.106741. Epub 2024 Jun 11.
The rise of antibiotic resistance poses a significant threat to public health worldwide, leading researchers to explore novel solutions to combat this growing problem. Nanotechnology, which involves manipulating materials at the nanoscale, has emerged as a promising avenue for developing novel strategies to combat antibiotic resistance. This cutting-edge technology has gained momentum in the medical field by offering a new approach to combating infectious diseases. Nanomaterial-based therapies hold significant potential in treating difficult bacterial infections by circumventing established drug resistance mechanisms. Moreover, their small size and unique physical properties enable them to effectively target biofilms, which are commonly linked to resistance development. By leveraging these advantages, nanomaterials present a viable solution to enhance the effectiveness of existing antibiotics or even create entirely new antibacterial mechanisms. This review article explores the current landscape of antibiotic resistance and underscores the pivotal role that nanotechnology plays in augmenting the efficacy of traditional antibiotics. Furthermore, it addresses the challenges and opportunities within the realm of nanotechnology for combating antibiotic resistance, while also outlining future research directions in this critical area. Overall, this comprehensive review articulates the potential of nanotechnology in addressing the urgent public health concern of antibiotic resistance, highlighting its transformative capabilities in healthcare.
抗生素耐药性的兴起对全球公共卫生构成了重大威胁，促使研究人员探索新的解决方案来应对这一日益严重的问题。纳米技术涉及在纳米尺度上操纵材料，已成为开发新型策略来对抗抗生素耐药性的有前途的途径。这项尖端技术在医疗领域的势头越来越猛，为治疗传染病提供了一种新方法。基于纳米材料的疗法具有很大的潜力，可以通过绕过现有的耐药机制来治疗困难的细菌感染。此外，它们的小尺寸和独特的物理特性使它们能够有效地靶向生物膜，生物膜通常与耐药性的发展有关。通过利用这些优势，纳米材料为增强现有抗生素的有效性甚至创造全新的抗菌机制提供了可行的解决方案。本文综述了抗生素耐药性的现状，并强调了纳米技术在增强传统抗生素疗效方面的关键作用。此外，它还讨论了纳米技术在对抗抗生素耐药性方面的挑战和机遇，同时概述了这一关键领域的未来研究方向。总的来说，这篇全面的综述阐述了纳米技术在解决抗生素耐药性这一紧迫的公共卫生问题方面的潜力，强调了其在医疗保健方面的变革性能力。
