Markowska-Szczupak Agata, Wróbel Rafał J, Kiełbus-Rąpała Anna, Michalkiewicz Beata
Department of Chemical and Process Engineering, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastow Ave. 42, 71-065 Szczecin, Poland.
Department of Catalytic and Sorbent Materials Engineering, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastow Ave. 42, 71-065 Szczecin, Poland.
Molecules. 2025 Aug 12;30(16):3348. doi: 10.3390/molecules30163348.
The growing prevalence of bacteria resistant to antibiotics and conventional disinfectants is a cause for concern and underscores the necessity of developing new strategies to prevent the transmission of microorganisms. To this end, nanocrystalline Cu, Au, and Ag nanoparticles were employed to fabricate various coatings using the sputtering technique. Then, the antibacterial activity of the coatings against Gram-negative and Gram-positive was investigated. The coating obtained by co-sputtering of Au, Ag, and Cu exhibited the most pronounced antibacterial properties. This coating was applied to disposable BIC ballpoint pens, which were subsequently used by clients in two public institutions. After three months of regular use, the antibacterial properties of the coatings were re-evaluated. It was confirmed that this coating led to a significant reduction (log5 CFU/mL) in the bacterial presence on the treated surface within 0.5 h. These results support further investigation into the underlying mechanism, which is likely based on the synergistic interaction of the employed noble metal nanoparticles.
对抗生素和传统消毒剂具有抗性的细菌日益普遍，这令人担忧，并凸显了开发预防微生物传播新策略的必要性。为此，采用纳米晶铜、金和银纳米颗粒，利用溅射技术制备了各种涂层。然后，研究了这些涂层对革兰氏阴性菌和革兰氏阳性菌的抗菌活性。通过共溅射金、银和铜获得的涂层表现出最显著的抗菌性能。这种涂层被应用于一次性BIC圆珠笔，随后由两个公共机构的客户使用。在正常使用三个月后，对涂层的抗菌性能进行了重新评估。结果证实，这种涂层在0.5小时内使处理过的表面上的细菌数量显著减少（log5 CFU/mL）。这些结果支持对潜在机制进行进一步研究，其可能基于所用贵金属纳米颗粒的协同相互作用。
