用于预测致癌物的遗传毒性数据库的构建与初步分析。
Assembly and preliminary analysis of a genotoxicity data base for predicting carcinogens.
作者信息
Palajda M, Rosenkranz H S
出版信息
Mutat Res. 1985 May;153(3):79-134. doi: 10.1016/0165-1110(85)90010-7.
PMID:3887150
Abstract
With a view to developing methodologies for predicting the carcinogenicity of chemicals on the basis of the results of short-term assays and selecting highly predictive batteries of short-term tests, a data base was assembled. The present is a compilation of data extracted from the reports of Gene-Tox working groups, Salmonella mutagenicity data obtained from the U.S. National Toxicology Program and the Environmental Mutagen Information Center and results from BHK21 transformation assays.
摘要
为了基于短期试验结果开发预测化学物质致癌性的方法，并选择具有高度预测性的短期试验组合，我们收集了一个数据库。本文是从基因毒性工作组报告中提取的数据、从美国国家毒理学计划和环境诱变信息中心获得的沙门氏菌诱变性数据以及BHK21转化试验结果的汇编。
相似文献
1
Assembly and preliminary analysis of a genotoxicity data base for predicting carcinogens.用于预测致癌物的遗传毒性数据库的构建与初步分析。
Mutat Res. 1985 May;153(3):79-134. doi: 10.1016/0165-1110(85)90010-7.
2
An approach to identifying specialized batteries of bioassays for specific classes of chemicals: class analysis using mutagenicity and carcinogenicity relationships and phylogenetic concordance and discordance patterns. 1. Composition and analysis of the overall data base. A report of phase II of the U.S. Environmental Protection Agency Gene-Tox Program.一种识别特定化学物质类别的生物测定专门组合的方法：利用致突变性和致癌性的关系以及系统发育一致性和不一致性模式进行类别分析。1. 总体数据库的组成与分析。美国环境保护局基因毒性计划第二阶段报告
Mutat Res. 1987 May;185(3):197-241. doi: 10.1016/0165-1110(87)90018-2.
3
Which rules for assembling short-term test batteries to predict carcinogenicity?哪些用于组装短期测试组合以预测致癌性的规则？
Mol Toxicol. 1987 Apr-Sep;1(2-3):143-66.
4
An analysis by chemical class of Salmonella mutagenicity tests as predictors of animal carcinogenicity.沙门氏菌致突变性试验化学类别分析作为动物致癌性预测指标的研究
Mutat Res. 1988 May-Aug;205(1-4):197-225. doi: 10.1016/0165-1218(88)90018-3.
5
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.根据化学结构、对沙门氏菌的致突变性以及美国国家毒理学计划测试的另外42种化学物质的致癌性水平进行分类。
Mutat Res. 1989 Jun;223(2):73-103. doi: 10.1016/0165-1218(89)90037-2.
6
Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program.根据化学结构、对沙门氏菌的致突变性以及美国国家毒理学计划测试的另外39种化学物质的致癌性水平进行分类。
Mutat Res. 1991 May;257(3):209-27. doi: 10.1016/0165-1110(91)90002-d.
7
The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the National Toxicology Program Data Base.
Mutat Res. 1990 Jan;228(1):51-80. doi: 10.1016/0027-5107(90)90014-u.
8
Application of the carcinogenicity prediction and battery selection (CPBS) method to the Gene-Tox data base.
Mutat Res. 1985 May;153(3):187-200. doi: 10.1016/0165-1110(85)90013-2.
9
The Salmonella typhimurium/mammalian microsomal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Mutat Res. 1986 Sep;168(2):69-240. doi: 10.1016/0165-1110(86)90002-3.
10
The genetic toxicity database of the National Toxicology Program: evaluation of the relationships between genetic toxicity and carcinogenicity.国家毒理学计划的遗传毒性数据库：遗传毒性与致癌性之间关系的评估
Environ Health Perspect. 1991 Dec;96:47-51. doi: 10.1289/ehp.919647.
引用本文的文献
1
Invited contribution: an objective approach to the development of short-term tests predictive of carcinogenicity.特邀稿件：一种用于开发预测致癌性短期试验的客观方法。
Cell Biol Toxicol. 1986 Dec;2(4):425-40. doi: 10.1007/BF00117846.
2
Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.化学物质与DNA共价结合指数致癌性的定量可预测性：体内和体外试验的比较。
Environ Health Perspect. 1990 Mar;84:183-92. doi: 10.1289/ehp.9084183.
3
Mathematical models for exploring different aspects of genotoxicity and carcinogenicity databases.用于探索遗传毒性和致癌性数据库不同方面的数学模型。
Environ Health Perspect. 1991 Dec;96:81-4. doi: 10.1289/ehp.919681.
4
Predicting mammalian mutagenesis by submammalian assays: an application of database GEN.通过亚哺乳动物试验预测哺乳动物诱变：数据库GEN的应用。
Environ Health Perspect. 1991 Dec;96:37-9. doi: 10.1289/ehp.96-1568224.
Zotero 插件