Tennant R W, Ashby J
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Mutat Res. 1991 May;257(3):209-27. doi: 10.1016/0165-1110(91)90002-d.
This paper is an extension of compilations published previously in this journal. (Ashby and Tennant, 1988; Ashby et al., 1989). A summary of the rodent carcinogenicity bioassay data on a further 39 chemicals tested by the U.S. National Toxicology Program (NTP) is presented. An evaluation of each chemical for structural alerts to DNA-reactivity is also provided, together with a summary of its mutagenicity to Salmonella. Chemicals with an aliphatic nitro group (-C-NO2) have been added to the composite structure of DNA-reactive sub-groups. The 39 chemicals were numbered and evaluated as an extension of the earlier analysis of 264 NTP chemicals. The activity patterns and conclusions derived from the earlier studies are followed by these 39 chemicals, albeit a detailed analysis of the total database of 301 chemicals is reserved for the succeeding paper.
本文是此前发表于本期刊的汇编文章的扩展内容。（阿什比和坦南特，1988年；阿什比等人，1989年）。本文呈现了美国国家毒理学计划（NTP）对另外39种化学品进行的啮齿动物致癌性生物测定数据的总结。同时还提供了对每种化学品DNA反应性结构警示的评估，以及其对沙门氏菌致突变性的总结。含有脂肪族硝基（-C-NO2）的化学品已被添加到DNA反应性子组的复合结构中。这39种化学品被编号，并作为对早期264种NTP化学品分析的扩展进行评估。这39种化学品遵循了早期研究得出的活性模式和结论，不过对301种化学品的完整数据库的详细分析将留待后续文章进行。
