Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of MRI, Kailuan General Hospital, Tangshan, Hebei Province, China.
Alzheimers Dement. 2024 Jul;20(7):4476-4485. doi: 10.1002/alz.13865. Epub 2024 Jun 13.
We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.
We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020.
Higher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume. Elevated DBPV was associated with lower volume of total brain and parietal GM, and higher white matter hyperintensity (WMH) volume. Higher SBPV and DBPV were associated with lower MoCA scores. Decreased total and regional GM volume and increased WMH volume were associated with lower MoCA scores. The association between SBPV and cognitive function was mediated by total, frontal, and temporal GM volume.
GM volume may play key roles in the association between SBPV and cognitive function.
SBPV and DBPV were negatively associated with total and regional brain volume. SBPV and DBPV were negatively associated with cognitive function. Decreased brain volume was associated with cognitive decline. GM volume mediated the negative association between SBPV and cognitive function.
我们描绘了长期血压变异性（BPV）、大脑结构和认知功能之间的关联。
我们纳入了来自开滦研究的 1254 名成年参与者。BPV 是从 2006 年到 2020 年计算的。2020 年进行了脑部磁共振成像（MRI）和蒙特利尔认知评估（MoCA）。
较高的收缩压变异性（SBPV）和舒张压变异性（DBPV）与总灰质（GM）和额 GM 体积减少相关，而较高的 SBPV 与颞 GM 体积减少相关。较高的 DBPV 与总脑和顶叶 GM 体积减少以及白质高信号（WMH）体积增加相关。较高的 SBPV 和 DBPV 与 MoCA 评分较低相关。总 GM 体积和区域 GM 体积减少以及 WMH 体积增加与 MoCA 评分较低相关。SBPV 和认知功能之间的关联是通过总 GM、额 GM 和颞 GM 体积来介导的。
GM 体积可能在 SBPV 和认知功能之间的关联中起着关键作用。
SBPV 和 DBPV 与总脑和区域脑容量呈负相关。SBPV 和 DBPV 与认知功能呈负相关。脑容量减少与认知能力下降有关。GM 体积介导了 SBPV 和认知功能之间的负相关。
