Huh Sung Woo, Cho Seong-Yong, Yoon Seongyong, Kim Daehwan, Park Hyun Woo, Kang Jisoo, Kim Keon Woo
Department of Occupational and Environmental Medicine, Soonchunhyang University Gumi Hospital, Gumi, Korea.
Ann Occup Environ Med. 2024 Apr 19;36:e12. doi: 10.35371/aoem.2024.36.e12. eCollection 2024.
Perfluoroalkyl substances (PFASs) are non-aromatic organic compounds, whose hydrogen atoms in the carbon chain substituted by fluorine atoms. PFASs exhibit developmental toxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, immunotoxicity, and hormone toxicity. PFASs are used in the production of disposable food packages, aircraft and automobile devices, cooking utensils, outdoor gear, furniture and carpets, aqueous film forming foam (AFFF), cables and wires, electronics, and semiconductors. This study aimed to determine the association between crustacean consumption and serum PFASs.
Adult participants (2,993) aged ≥ 19 years were extracted from the 4th cycle data of the Korean National Environmental Health Survey (KoNEHS). Based on the 50th percentile concentrations of serum PFASs, participants were divided into the low-concentration group (LC) and the high-concentration group (HC). General characteristics, dietary factors, coated product usage, and personal care product usage, an independent t-test and χ test were analyzed. The odds ratio (OR) of serum PFAS concentration against crustacean consumption was estimated via logistic regression analysis adjusting for general characteristics, dietary factors, coated product usage, and personal care product usage.
The OR for the HC of serum PFASs was higher in individuals with ≥once a week crustacean consumption than in those with < once a week crustacean consumption. Estimated ORs were perfluorohexanesulfonic acid 2.15 (95% confidence interval [CI]: 1.53-3.02), perfluorononanoic acid (PFNA) 1.23 (95% CI: 1.07-1.41), and perfluorodecanoic acid (PFDeA) 1.42 (95% CI: 1.17-1.74) in males, and perfluorooctanoic acid 1.48 (95% CI: 1.19-1.84), perfluorooctanesulfonic acid 1.39 (95% CI: 1.27-1.52), PFNA 1.70 (95% CI: 1.29-2.26) and PFDeA 1.43 (95% CI: 1.32-1.54) in females.
This study revealed the association between the crustacean consumption and concentrations of serum PFASs in general Korean population.
全氟烷基物质（PFASs）是一类非芳香族有机化合物，其碳链上的氢原子被氟原子取代。PFASs具有发育毒性、致癌性、肝毒性、生殖毒性、免疫毒性和激素毒性。PFASs被用于生产一次性食品包装、飞机和汽车设备、炊具、户外装备、家具和地毯、水成膜泡沫（AFFF）、电缆电线、电子产品和半导体。本研究旨在确定食用甲壳类动物与血清PFASs之间的关联。
从韩国国家环境卫生调查（KoNEHS）的第4轮数据中提取年龄≥19岁的成年参与者（2993名）。根据血清PFASs的第50百分位数浓度，将参与者分为低浓度组（LC）和高浓度组（HC）。分析一般特征、饮食因素、涂层产品使用情况和个人护理产品使用情况，采用独立t检验和χ检验。通过对一般特征、饮食因素、涂层产品使用情况和个人护理产品使用情况进行调整的逻辑回归分析，估计血清PFAS浓度与食用甲壳类动物的比值比（OR）。
每周食用甲壳类动物≥1次的个体中，血清PFASs高浓度组的OR高于每周食用甲壳类动物<1次的个体。男性中，全氟己烷磺酸的估计OR为2.15（95%置信区间[CI]：1.53 - 3.02），全氟壬酸（PFNA）为1.23（95% CI：1.07 - 1.41），全氟癸酸（PFDeA）为1.42（95% CI：1.17 - 1.74）；女性中，全氟辛酸为1.48（95% CI：1.19 - 1.84），全氟辛烷磺酸为1.39（95% CI：1.27 - 1.52），PFNA为1.70（95% CI：1.29 - 2.26），PFDeA为1.43（95% CI：1.32 - 1.54）。
本研究揭示了韩国普通人群中食用甲壳类动物与血清PFASs浓度之间的关联。
