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生物活性玻璃1393通过ROS/P53/MMP9信号通路促进血管生成并加速伤口愈合。

Bioactive glass 1393 promotes angiogenesis and accelerates wound healing through ROS/P53/MMP9 signaling pathway.

作者信息

Chen Xuenan, Ran Xinyu, Wei Xuebo, Zhu Lifei, Chen Shaodong, Liao Zhiyong, Xu Ke, Xia Weidong

机构信息

National Key Clinical Specialty(Wound Healing), Burn and Wound Healing Center, The First Affliated Hospital of Wenzhou Medical University, Wenzhou, China.

College of Life and Environmental Sciences, Wenzhou University, Zhejiang, China.

出版信息

Regen Ther. 2024 May 31;26:132-144. doi: 10.1016/j.reth.2024.05.016. eCollection 2024 Jun.

DOI:10.1016/j.reth.2024.05.016
PMID:38872979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11169082/
Abstract

Compared to bioactive glass 45S5, bioactive glass 1393 has shown greater potential in activating tissue cells and promoting angiogenesis for bone repair. Nevertheless, the effect of bioactive glass 1393 in the context of wound healing remains extensively unexplored, and its mechanism in wound healing remains unclear. Considering that angiogenesis is a critical stage in wound healing, we hypothesize that bioactive glass 1393 may facilitate wound healing through the stimulation of angiogenesis. To validate this hypothesis and further explore the mechanisms underlying its pro-angiogenic effects, we investigated the impact of bioactive glass 1393 on wound healing angiogenesis through both and studies. The research demonstrated that bioactive glass 1393 accelerated wound healing by promoting the formation of granulation, deposition of collagen, and angiogenesis. The results of Western blot analysis and immunofluorescence staining revealed that bioactive glass 1393 up-regulated the expression of angiogenesis-related factors. Additionally, bioactive glass 1393 inhibited the expression of ROS and P53 to promote angiogenesis. Furthermore, bioactive glass 1393 stimulated angiogenesis through the P53 signaling pathway, as evidenced by P53 activation assays. Collectively, these findings indicate that bioactive glass 1393 accelerates wound healing by promoting angiogenesis via the ROS/P53/MMP9 signaling pathway.

摘要

与生物活性玻璃45S5相比，生物活性玻璃1393在激活组织细胞和促进骨修复血管生成方面显示出更大的潜力。然而，生物活性玻璃1393在伤口愈合背景下的作用仍未得到广泛探索，其在伤口愈合中的机制也尚不清楚。鉴于血管生成是伤口愈合的关键阶段，我们推测生物活性玻璃1393可能通过刺激血管生成来促进伤口愈合。为了验证这一假设并进一步探索其促血管生成作用的潜在机制，我们通过体内和体外研究调查了生物活性玻璃1393对伤口愈合血管生成的影响。研究表明，生物活性玻璃1393通过促进肉芽形成、胶原蛋白沉积和血管生成来加速伤口愈合。蛋白质免疫印迹分析和免疫荧光染色结果显示，生物活性玻璃1393上调了血管生成相关因子的表达。此外，生物活性玻璃1393抑制ROS和P53的表达以促进血管生成。此外，如P53激活试验所证明的，生物活性玻璃1393通过P53信号通路刺激血管生成。总的来说，这些发现表明生物活性玻璃1393通过ROS/P53/MMP9信号通路促进血管生成，从而加速伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/7baf6ad0fbdc/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/e46f7ad4a2bd/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/4d0b265d1606/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/e054d67f723d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/65d9a53dc46b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/a4b33c68d9ba/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/2fed763eee1c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/7baf6ad0fbdc/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/e46f7ad4a2bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/ac569d5e60b5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/4d0b265d1606/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/e054d67f723d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/65d9a53dc46b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/a4b33c68d9ba/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/2fed763eee1c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/11169082/7baf6ad0fbdc/gr8.jpg

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