内源性雄激素、疑似缺血性心脏病女性的冠状动脉粥样硬化与重塑：女性缺血综合征评估（WISE）研究报告
Endogenous androgens, coronary atheroma and remodeling in women with suspected ischemic heart disease: A report from the Women's Ischemia Syndrome Evaluation (WISE) study.
作者信息
Ranasinghe Sachini, Jain Ankur, Taha Yasmeen, Handberg Eileen, Johnson B Delia, Bittner Vera, Sopko George, Pepine Carl J, Anderson R David, Merz C Noel Bairey
机构信息
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.
Division of Cardiology, Department of Medicine, University of Florida, Gainesville, FL, United States of America.
出版信息
Am Heart J Plus. 2024 May 31;43:100411. doi: 10.1016/j.ahjo.2024.100411. eCollection 2024 Jul.
BACKGROUND
Women have smaller coronary size than men independent of body surface area. Female to male heart transplantation demonstrates coronary lumen enlargement.
PURPOSE
To investigate relationships between endogenous androgens and coronary luminal size in women with suspected ischemic heart disease (IHD).
METHODS
We analyzed 69 women with available androgen levels.
RESULTS
Group mean age was 54 ± 10 years with 64 % post-menopausal. Lumen cross-sectional area (CSA) and external elastic membrane (EEM) CSA positively correlated with free testosterone (FT) ( = 0.29, = 0.049; r = 0.29, = 0.01), respectively, and negatively correlated with SHBG ( = -0.26, = 0.03; = -0.29, = 0.02), respectively. Atheroma CSA positively correlated with FT ( = 0.24. = 0.05). These correlations became non-significant after adjusting for waist circumference.
CONCLUSIONS
In women with suspected ischemic heart disease, endogenous androgens, coronary atheroma and luminal size are related, and may be moderated by waist circumference.
背景
女性的冠状动脉尺寸比男性小，与体表面积无关。女性到男性的心脏移植显示冠状动脉管腔扩大。
目的
研究疑似缺血性心脏病（IHD）女性体内内源性雄激素与冠状动脉管腔大小之间的关系。
方法
我们分析了69名有可用雄激素水平的女性。
结果
组平均年龄为54±10岁，64%为绝经后女性。管腔横截面积（CSA）和外弹性膜（EEM）CSA分别与游离睾酮（FT）呈正相关（P = 0.29，P = 0.049；r = 0.29，P = 0.01），与性激素结合球蛋白（SHBG）分别呈负相关（P = -0.26，P = 0.03；P = -0.29，P = 0.02）。动脉粥样硬化CSA与FT呈正相关（P = 0.24，P = 0.05）。在校正腰围后，这些相关性变得不显著。
结论
在疑似缺血性心脏病的女性中，内源性雄激素、冠状动脉粥样硬化和管腔大小相关，且可能受腰围影响。
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