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Preparation of antiviral multispray with cationic antimicrobial dialkyldimethyl ammonium salt and sulfobetaine against new coronaviruses (SARS-CoV-2).用阳离子抗菌二烷基二甲基铵盐和磺基甜菜碱制备抗新型冠状病毒(SARS-CoV-2)的抗病毒多喷雾制剂。
Access Microbiol. 2024 May 31;6(5). doi: 10.1099/acmi.0.000631.v5. eCollection 2024.
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本文引用的文献

1
Increased Use of Quaternary Ammonium Compounds during the SARS-CoV-2 Pandemic and Beyond: Consideration of Environmental Implications.严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行期间及之后季铵化合物使用量的增加:对环境影响的考量
Environ Sci Technol Lett. 2020 Jun 26;7(9):622-631. doi: 10.1021/acs.estlett.0c00437. eCollection 2020 Sep 8.
2
Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2.洗必泰漱口液对 SARS-CoV-2 的抗病毒作用。
Sci Rep. 2022 Aug 18;12(1):14050. doi: 10.1038/s41598-022-18367-6.
3
An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening.一种用于SARS-CoV-2血清学和药物筛选的体外微量中和试验。
Curr Protoc Microbiol. 2020 Sep;58(1):e108. doi: 10.1002/cpmc.108.
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Alcohol: intolerance syndromes, urticarial and anaphylactoid reactions.酒精:不耐受综合征、荨麻疹及类过敏反应。
Clin Dermatol. 1999 Jul-Aug;17(4):417-22. doi: 10.1016/s0738-081x(99)00027-9.
5
Alcohol dermatitis: allergic contact dermatitis and contact urticaria syndrome. A review.酒精性皮炎:过敏性接触性皮炎和接触性荨麻疹综合征。综述。
Contact Dermatitis. 1994 Jan;30(1):1-6. doi: 10.1111/j.1600-0536.1994.tb00719.x.
6
Topically applied alcohol as a cause of contact dermatitis.外用酒精作为接触性皮炎的一个病因。
Cutis. 1983 Jun;31(6):588, 592, 600.
7
Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese.醛脱氢酶缺乏是日本人饮酒后面部潮红反应的原因。
Lancet. 1981 Oct 31;2(8253):982. doi: 10.1016/s0140-6736(81)91172-7.

用阳离子抗菌二烷基二甲基铵盐和磺基甜菜碱制备抗新型冠状病毒(SARS-CoV-2)的抗病毒多喷雾制剂。

Preparation of antiviral multispray with cationic antimicrobial dialkyldimethyl ammonium salt and sulfobetaine against new coronaviruses (SARS-CoV-2).

作者信息

Morioka Masahiko, Shimaoka Daisuke, Ohnishi Mamoru

机构信息

Graduate School of Science, Osaka Metropolitan University, 1-2 Garden-cho, Naka-kuSakai, Osaka 599-8570, Japan.

Printemps Co., Ltd, 992-1 Toichi-machi, Kashihara, Nara 634-0008, Japan.

出版信息

Access Microbiol. 2024 May 31;6(5). doi: 10.1099/acmi.0.000631.v5. eCollection 2024.

DOI:10.1099/acmi.0.000631.v5
PMID:38873577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11170126/
Abstract

The novel sudden acute respiratory syndrome coronavirus 2 is an enveloped virus currently causing severe illness and death worldwide. Common antiseptics such as alcohol have some efficacy in disinfecting everyday surroundings, but development of more effective disinfectants is imperative. A series of studies focusing on cationic antimicrobials resulted in the development of a safe and effective novel coronavirus disinfectant, DEA-171, which provides ≥99.98 % inhibition of all novel coronavirus variants within 1 min.

摘要

新型严重急性呼吸综合征冠状病毒2是一种包膜病毒,目前正在全球范围内导致严重疾病和死亡。常见的消毒剂如酒精在日常环境消毒方面有一定效果,但开发更有效的消毒剂势在必行。一系列针对阳离子抗菌剂的研究促成了一种安全有效的新型冠状病毒消毒剂DEA-171的开发,该消毒剂在1分钟内对所有新型冠状病毒变体的抑制率≥99.98%。