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牙周病与新兴即时检测技术的诊断应用

Periodontal disease and emerging point-of-care technologies for its diagnosis.

机构信息

Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.

Center for Remote Health Technologies and Systems, Texas A&M Engineering and Experiment Station, College Station, TX 77843, USA.

出版信息

Lab Chip. 2024 Jul 10;24(14):3326-3346. doi: 10.1039/d4lc00295d.

Abstract

Periodontal disease (PD), a chronic inflammatory disorder that damages the tooth and its supporting components, is a common global oral health problem. Understanding the intricacies of these disorders, from gingivitis to severe PD, is critical for efficient treatment, diagnosis, and prevention in dental care. Periodontal biosensors and biomarkers are critical in improving oral health diagnostic skills. Clinicians may accomplish early identification, tailored therapy, and efficient tracking of periodontal diseases by using these technologies, ushering in a new age of accurate oral healthcare. Traditional periodontitis diagnostic methods frequently rely on physical probing and visual examinations, necessitating the development of point-of-care (POC) devices. As periodontal disorders necessitate more precise and rapid diagnosis, incorporating novel innovations in biosensors and biomarkers becomes increasingly crucial. These innovations improve our capacity to diagnose, monitor, and adapt periodontal therapies, bringing in the next phase of customized and effective dental healthcare. The review discusses the characteristics and stages of PD, clinical treatment techniques, prominent biomarkers and infection-associated factors that may be employed to determine PD, biomedical sensing, and POC appliances that have been created so far to diagnose stages of PD and its progression profile, as well as predicting future developments in this field.

摘要

牙周病(PD)是一种慢性炎症性疾病,会损害牙齿及其支持组织,是一种常见的全球口腔健康问题。了解从牙龈炎到严重 PD 等各种牙周病的细微差别,对于口腔护理中的有效治疗、诊断和预防至关重要。牙周生物传感器和生物标志物对于提高口腔健康诊断能力至关重要。临床医生可以通过使用这些技术实现早期识别、定制治疗和对牙周病的有效跟踪,开创口腔保健的新时代。传统的牙周炎诊断方法通常依赖于物理探测和目视检查,因此需要开发即时护理(POC)设备。由于牙周病需要更精确和快速的诊断,因此生物传感器和生物标志物的创新变得越来越重要。这些创新提高了我们诊断、监测和调整牙周治疗的能力,带来了个性化和有效的牙科医疗保健的新阶段。本文综述了 PD 的特征和阶段、临床治疗技术、可能用于确定 PD 的突出生物标志物和感染相关因素、生物医学传感以及迄今为止为诊断 PD 及其进展情况而开发的 POC 设备,以及对该领域未来发展的预测。

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