控制棕色脂肪组织发育的因素。

Factors controlling brown adipose tissue development.

作者信息

Ricquier D, Mory G, Bouillaud F, Combes-George M, Thibault J

出版信息

Reprod Nutr Dev (1980). 1985;25(1B):175-81. doi: 10.1051/rnd:19850205.

DOI:10.1051/rnd:19850205

Abstract

Brown adipose tissue (BAT) is a site of non-shivering thermogenesis in mammals. Thermogenesis in brown adipocytes is related to the presence of a specific mitochondrial component called "uncoupling protein". When animals are chronically exposed to cold, their BAT is enlarged and exhibits several changes such as cellular differentiation, hyperplasia, mitochondriogenesis and marked synthesis of uncoupling protein. The hormonal and neural factors controlling this adaptive response have been studied. It is concluded that sympathetic innervation of BAT and released noradrenaline play an essential role in the development of BAT.

摘要

棕色脂肪组织（BAT）是哺乳动物非颤抖性产热的部位。棕色脂肪细胞中的产热与一种名为“解偶联蛋白”的特定线粒体成分的存在有关。当动物长期暴露于寒冷环境时，它们的棕色脂肪组织会增大，并表现出细胞分化、增生、线粒体生成和解偶联蛋白的显著合成等多种变化。已经对控制这种适应性反应的激素和神经因素进行了研究。得出的结论是，棕色脂肪组织的交感神经支配和释放的去甲肾上腺素在棕色脂肪组织的发育中起着至关重要的作用。