唤醒沉睡的巨人：单链 DNA 结合 Schlafen 11 以启动先天免疫反应。
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses.
机构信息
Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Sci Immunol. 2024 Jun 14;9(96):eadp4474. doi: 10.1126/sciimmunol.adp4474.
PMID:38875318
Abstract
Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang ).
摘要
含有 CGT/A 基序的单链 DNA 与 Schlafen 11（SLFN11）的解旋酶结构域结合，通过 SLFN11 核糖核酸酶活性引发细胞死亡和细胞因子产生（见张的相关研究文章）。
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