Schwarz D A, Katayama C D, Hedrick S M
Cancer Center and the Department of Biology, University of California, San Diego, La Jolla 92093-0687, USA.
Immunity. 1998 Nov;9(5):657-68. doi: 10.1016/s1074-7613(00)80663-9.
The Schlafen (Slfn) family of genes are differentially regulated during thymocyte maturation and are preferentially expressed in the lymphoid tissues. Ectopic expression of the prototype member Slfn1 early in the T lineage profoundly alters cell growth and development. In these mice, the DP thymocytes fail to complete maturation, and, depending on the transgene dosage, the number of thymocytes is reduced to 1%-30% of normal. Furthermore, expression of the Schlafen family members in fibroblasts and thymoma cells either retards or ablates cell growth. The conceptual protein sequences deduced for each of the family members have no similarity to characterized proteins and must therefore participate in a heretofore unknown regulatory mechanism guiding both cell growth and T cell development.
施拉芬（Slfn）基因家族在胸腺细胞成熟过程中受到不同程度的调控，且在淋巴组织中优先表达。T细胞谱系早期原型成员Slfn1的异位表达会深刻改变细胞的生长和发育。在这些小鼠中，双阳性（DP）胸腺细胞无法完成成熟，并且根据转基因剂量的不同，胸腺细胞数量会减少至正常水平的1% - 30%。此外，施拉芬家族成员在成纤维细胞和胸腺瘤细胞中的表达会抑制或消除细胞生长。推导得出的每个家族成员的概念性蛋白质序列与已鉴定的蛋白质没有相似性，因此必定参与了一种迄今为止未知的指导细胞生长和T细胞发育的调控机制。
