Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jiangxi Province Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Medicine (Baltimore). 2024 Jun 14;103(24):e38490. doi: 10.1097/MD.0000000000038490.
Previous observational studies have suggested a possible association between periodontal disease and gastric cancer (GC); however, a causal relationship has not yet been established. This study aimed to explore the causal relationship between the 2 through a 2-sample bidirectional Mendelian randomization (MR) study.
Genome-wide association studies (GWAS) summary statistics were obtained from publicly available GWAS and relevant databases. Two-sample bidirectional MR analysis was conducted to investigate the causal relationship between periodontal disease and GC using the inverse-variance weighted (IVW) method selected as the primary analytical approach. Cochran Q test, MR-PRESSO, MR-pleiotropy, and leave-one-out analyses were performed to assess heterogeneity, pleiotropy, and sensitivity.
In European ancestry, IVW analysis revealed no causal relationship between periodontal disease and GC (OR = 1.873; 95% CI [4.788e-10, 7.323e + 09]; P = .956), or between loose teeth and GC (OR = 1.064; 95% CI [0.708, 1.598]; P = .765). In East Asian ancestry, there was no causal relationship between periodontitis and GC according to IVW (OR = 0.948; 95% CI [0.886, 1.015]; P = .126). Conversely, according to the results of the IVW analysis, there was no causal relationship between GC and periodontal disease, regardless of European or East Asian ancestry. Furthermore, there was no heterogeneity or pleiotropy in the causal relationships between these variables (all P > .05), suggesting a certain level of reliability in our results.
Within the limitations of this MR study, we found no mutual causal relationship between periodontal disease and GC. This finding can prevent overtreatment by clinical physicians and alleviate the psychological burden on patients.
先前的观察性研究表明，牙周病与胃癌（GC）之间可能存在关联，但尚未确定因果关系。本研究旨在通过两样本双向孟德尔随机化（MR）研究探索两者之间的因果关系。
从公开可用的 GWAS 和相关数据库中获取全基因组关联研究（GWAS）汇总统计数据。使用作为主要分析方法的逆方差加权（IVW）方法，进行两样本双向 MR 分析，以探讨牙周病与 GC 之间的因果关系。使用 Cochran Q 检验、MR-PRESSO、MR 多效性和剔除一个分析来评估异质性、多效性和敏感性。
在欧洲血统中，IVW 分析显示牙周病与 GC 之间没有因果关系（OR=1.873；95%CI [4.788e-10, 7.323e+09]；P=.956），或松动牙齿与 GC 之间没有因果关系（OR=1.064；95%CI [0.708, 1.598]；P=.765）。在东亚血统中，根据 IVW，牙周炎与 GC 之间也没有因果关系（OR=0.948；95%CI [0.886, 1.015]；P=.126）。相反，根据 IVW 分析的结果，牙周病与 GC 之间没有因果关系，无论欧洲或东亚血统。此外，这些变量之间的因果关系没有异质性或多效性（所有 P>.05），这表明我们的结果具有一定的可靠性。
在本 MR 研究的限制范围内，我们没有发现牙周病与 GC 之间存在相互因果关系。这一发现可以防止临床医生过度治疗，并减轻患者的心理负担。
