Verma Umesh P, Singh Pooja, Verma Ajay K
Department of Periodontology, King George's Medical University, Lucknow, IND.
Department of Pulmonary Medicine, King George's Medical University, Lucknow, IND.
Cureus. 2023 Mar 21;15(3):e36476. doi: 10.7759/cureus.36476. eCollection 2023 Mar.
Periodontal disease is associated with many systemic diseases, such as cardiovascular diseases, atherosclerosis, diabetes mellitus, stroke, and pulmonary diseases. Interestingly, recent literature suggests that periodontal disease might be a risk factor for various cancers such as lung, colon, oesophageal, head, and neck cancers. However, the precise mechanistic link is lacking. Hence, in this meta-analysis, we aimed to investigate the correlation between periodontal disease and lung cancer in periodontally diseased patients. Data were searched for relevant studies from 2010 to 2022. We correlated periodontal disease and lung cancer based on adjusted ORs/HRs and associated CIs. I2 statistic was used to assess statistical heterogeneity. Publication bias was analyzed by visually inspecting the symmetry of the funnel plot and Egger's test. The study is registered in the International Prospective Register of Systematic Reviews (PROSPERO; registration no: CRD42023390819). A total of 194,850 participants from observational studies (two case-control studies and five cohort studies) were incorporated for the current analysis. The meta-analysis of included studies showed an overall effect size (risk ratio) of the periodontal disease group with respect to the non-periodontal disease group for lung neoplasm to be 1.41 (95% CI: 1.32-1.52). The value was more than 1, indicating that the periodontal disease group had a relatively higher lung cancer prevalence than the non-periodontal disease group. Further, the overall risk ratio was found to be statistically significant (p<0.00001). Moreover, the funnel plot suggested some degree of publication bias. Evidence in our study implicated that there is an increased risk of occurrence of lung cancer in chronic periodontitis patients.
牙周疾病与许多全身性疾病相关，如心血管疾病、动脉粥样硬化、糖尿病、中风和肺部疾病。有趣的是，最近的文献表明，牙周疾病可能是多种癌症的危险因素，如肺癌、结肠癌、食管癌、头颈癌。然而，缺乏确切的机制联系。因此，在这项荟萃分析中，我们旨在研究牙周疾病患者中牙周疾病与肺癌之间的相关性。检索了2010年至2022年的相关研究数据。我们基于调整后的比值比/风险比及相关的可信区间来关联牙周疾病和肺癌。I²统计量用于评估统计异质性。通过直观检查漏斗图的对称性和Egger检验来分析发表偏倚。该研究已在国际系统评价前瞻性注册库（PROSPERO；注册号：CRD42023390819）注册。本分析纳入了来自观察性研究（两项病例对照研究和五项队列研究）的总共194,850名参与者。纳入研究的荟萃分析显示，牙周疾病组相对于非牙周疾病组的肺癌总体效应量（风险比）为1.41（95%可信区间：1.32 - 1.52）。该值大于1，表明牙周疾病组的肺癌患病率相对高于非牙周疾病组。此外，总体风险比具有统计学意义（p<0.00001）。而且，漏斗图显示存在一定程度的发表偏倚。我们研究中的证据表明，慢性牙周炎患者患肺癌的风险增加。
