Department of Translational Medicine, University of Ferrara, Via Luigi Borsari, Ferrara, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari, Ferrara, Italy.
Adv Nutr. 2024 Jul;15(7):100252. doi: 10.1016/j.advnut.2024.100252. Epub 2024 Jun 12.
Impaired lipid metabolism is a pivotal driver of cardiovascular disease (CVD). In this regard, the accumulation of ceramides within the circulation as well as in metabolically active tissues and atherosclerotic plaques is a direct consequence of derailed lipid metabolism. Ceramides may be at the nexus between impaired lipid metabolism and CVD. Indeed, although on one hand ceramides have been implicated in the pathogenesis of CVD, on the other specific ceramide subspecies have also been proposed as predictors of major adverse cardiovascular events. This review will provide an updated overview of the role of ceramides in the pathogenesis of CVD, as well as their pathogenetic mechanisms of action. Furthermore, the manuscript will cover the importance of ceramides as biomarkers to predict cardiovascular events and the role of diet, both in terms of nutrients and dietary patterns, in modulating ceramide metabolism and homeostasis.
脂质代谢异常是心血管疾病 (CVD) 的关键驱动因素。在这方面，神经酰胺在循环系统以及代谢活跃的组织和动脉粥样硬化斑块中的积累是脂质代谢失调的直接后果。神经酰胺可能是脂质代谢异常和 CVD 之间的联系。事实上，尽管一方面神经酰胺被认为与 CVD 的发病机制有关，但另一方面，特定的神经酰胺亚种也被提出作为主要不良心血管事件的预测因子。本文将提供神经酰胺在 CVD 发病机制中的作用以及其作用机制的最新概述。此外，本文还将介绍神经酰胺作为预测心血管事件的生物标志物的重要性，以及饮食在调节神经酰胺代谢和平衡方面的作用，包括营养素和饮食模式。
