Gaggini Melania, Suman Adrian Florentin, Vassalle Cristina
Institute of Clinical Physiology, National Research Council, Via G. Moruzzi 1, 56124 Pisa, Italy.
Fondazione CNR-Regione Toscana G Monasterio, Via G. Moruzzi 1, 56124 Pisa, Italy.
Metabolites. 2025 Mar 1;15(3):168. doi: 10.3390/metabo15030168.
Lipids are a complex entity of different molecules, among which ceramides (Cers), ubiquitous sphingolipids with remarkable biological activity, can represent a potential additive biomarker that can be used to better understand the underlying mechanisms which drive the onset and development of atherosclerotic damage and plaque vulnerability and facilitate coronary disease management, as possible risk/prognostic biomarkers and targets for therapeutic intervention. Accordingly, this review aims to discuss the available results on the role Cersplay in contributing to atherosclerosis development and acute coronary event precipitation, their impact on complications and adverse prognosis, as well as the impact of treatment options in modulating Cerlevels.
脂质是由不同分子组成的复杂物质，其中神经酰胺（Cers）是普遍存在的具有显著生物活性的鞘脂，它可能是一种潜在的附加生物标志物，可用于更好地理解驱动动脉粥样硬化损伤和斑块易损性发生发展的潜在机制，并作为可能的风险/预后生物标志物及治疗干预靶点来促进冠心病的管理。因此，本综述旨在讨论关于神经酰胺在动脉粥样硬化发展和急性冠脉事件诱发中所起作用的现有研究结果，它们对并发症和不良预后的影响，以及治疗方案对神经酰胺水平的调节作用。
