Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Hope Clinic of Emory Vaccine Center, 500 Irvin Court, Suite 200, Decatur, GA 30030, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Infect Dis Clin North Am. 2024 Sep;38(3):475-485. doi: 10.1016/j.idc.2024.04.004. Epub 2024 Jun 13.
Development of a safe and effective human immunodeficiency virus (HIV) vaccine is a persistent challenge despite decades of research. Previous strategies utilizing protein subunit and viral vector vaccines were safe but not protective. Current strategies seek to induce broadly neutralizing antibodies, with multiple early phase trials in progress seeking to achieve this through sequential vaccination, mRNA, or updated viral-vectored vaccines. A safe and effective vaccine is critical to ending the HIV epidemic.
尽管已经进行了几十年的研究，但开发安全有效的人类免疫缺陷病毒 (HIV) 疫苗仍然是一个持续存在的挑战。以前使用蛋白亚单位和病毒载体疫苗的策略是安全的，但没有保护作用。目前的策略旨在诱导广泛中和抗体，目前正在进行多项早期临床试验，试图通过序贯接种、mRNA 或更新的病毒载体疫苗来实现这一目标。安全有效的疫苗对于结束 HIV 流行至关重要。
