• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用糖醇对丝素蛋白进行亲水性和物理化学性质的定制，用于医疗器械涂层。

Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings.

机构信息

Department of Chemistry, Faculty of Science, Burapha University, Chonburi, 20131, Thailand.

Department of Medical Science, National Institute of Health, Ministry of Public Health, Nonthaburi, 11000, Thailand.

出版信息

Sci Rep. 2024 Jun 14;14(1):13781. doi: 10.1038/s41598-024-64450-5.

DOI:10.1038/s41598-024-64450-5
PMID:38877138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11178791/
Abstract

This study explores the modification of silk fibroin films for hydrophilic coating applications using various sugar alcohols. Films, prepared via solvent casting, incorporated glycerol, sorbitol, and maltitol, revealing distinctive transparency and UV absorption characteristics based on sugar alcohol chemical structures. X-ray diffraction confirmed a silk I to silk II transition influenced by sugar alcohols. Glycerol proved most effective in enhancing the β-sheet structure. The study also elucidated a conformational shift towards a β-sheet structure induced by sugar alcohols. Silk fibroin-sugar alcohol blind docking and sugar alcohol-sugar alcohol blind docking investigations were conducted utilizing the HDOCK Server. The computer simulation unveiled the significance of size and hydrogen bonding characteristics inherent in sugar alcohols, emphasizing their pivotal role in influencing interactions within silk fibroin matrices. Hydrophilicity of ozonized silicone surfaces improved through successful coating with silk fibroin films, particularly glycerol-containing ones, resulting in reduced contact angles. Strong adhesion between silk fibroin films and ozonized silicone surfaces was evident, indicating robust hydrogen bonding interactions. This comprehensive research provides crucial insights into sugar alcohols' potential to modify silk fibroin film crystalline structures, offering valuable guidance for optimizing their design and functionality, especially in silicone coating applications.

摘要

本研究探索了使用各种糖醇对丝素蛋白薄膜进行亲水涂层应用的改性。通过溶剂浇铸制备的薄膜中加入了甘油、山梨糖醇和麦芽糖醇，根据糖醇的化学结构呈现出独特的透明度和紫外吸收特性。X 射线衍射证实了丝素 I 向丝素 II 的转变受到糖醇的影响。甘油被证明在增强β-折叠结构方面最为有效。该研究还阐明了糖醇诱导的构象向β-折叠结构的转变。利用 HDOCK Server 进行了丝素蛋白-糖醇盲对接和糖醇-糖醇盲对接研究。计算机模拟揭示了糖醇大小和氢键特征的重要性，强调了它们在影响丝素蛋白基质内相互作用方面的关键作用。通过成功地用丝素蛋白薄膜对硅氧烷表面进行涂层处理，提高了硅氧烷表面的亲水性，特别是含有甘油的薄膜，导致接触角降低。丝素蛋白薄膜和臭氧硅氧烷表面之间具有很强的附着力，表明存在牢固的氢键相互作用。这项综合研究深入了解了糖醇对丝素蛋白薄膜结晶结构的改性潜力，为优化其设计和功能提供了有价值的指导，特别是在硅氧烷涂层应用中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/35837c4d2884/41598_2024_64450_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/b99f57776d3e/41598_2024_64450_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/825db12cd107/41598_2024_64450_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/2e8fb8c83dec/41598_2024_64450_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/edb146d9471a/41598_2024_64450_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/d249138ea811/41598_2024_64450_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/23b0907183e8/41598_2024_64450_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/a1f2fdbf94f9/41598_2024_64450_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/35837c4d2884/41598_2024_64450_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/b99f57776d3e/41598_2024_64450_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/825db12cd107/41598_2024_64450_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/2e8fb8c83dec/41598_2024_64450_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/edb146d9471a/41598_2024_64450_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/d249138ea811/41598_2024_64450_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/23b0907183e8/41598_2024_64450_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/a1f2fdbf94f9/41598_2024_64450_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a894/11178791/35837c4d2884/41598_2024_64450_Fig8_HTML.jpg

相似文献

1
Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings.使用糖醇对丝素蛋白进行亲水性和物理化学性质的定制，用于医疗器械涂层。
Sci Rep. 2024 Jun 14;14(1):13781. doi: 10.1038/s41598-024-64450-5.
2
Thai silk fibroin gelation process enhancing by monohydric and polyhydric alcohols.一元醇和多元醇促进泰国丝素凝胶化过程。
Int J Biol Macromol. 2018 Oct 15;118(Pt B):1726-1735. doi: 10.1016/j.ijbiomac.2018.07.017. Epub 2018 Jul 11.
3
Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation.表面活化法制备丝素蛋白膜涂层的 MgZnCa 合金，具有增强的体外和体内性能。
Acta Biomater. 2019 Jun;91:99-111. doi: 10.1016/j.actbio.2019.04.048. Epub 2019 Apr 24.
4
Comparison of the knitted silk vascular grafts coated with fibroin sponges prepared using glycerin, poly(ethylene glycol diglycidyl ether) and poly(ethylene glycol) as porogens.以甘油、聚（乙二醇二缩水甘油醚）和聚（乙二醇）作为致孔剂制备的丝素海绵涂层针织丝素血管移植物的比较。
J Biomater Appl. 2018 Apr;32(9):1239-1252. doi: 10.1177/0885328218758276. Epub 2018 Feb 15.
5
Silk coatings on PLGA and alginate microspheres for protein delivery.用于蛋白质递送的PLGA和藻酸盐微球上的丝素涂层。
Biomaterials. 2007 Oct;28(28):4161-9. doi: 10.1016/j.biomaterials.2007.05.036. Epub 2007 Jun 20.
6
Development of antibiotic-loaded silk fibroin/hyaluronic acid polyelectrolyte film coated CoCrMo alloy.载抗生素的丝素蛋白/透明质酸聚电解质膜包覆钴铬钼合金的研制
Biomed Tech (Berl). 2016 Oct 1;61(5):463-474. doi: 10.1515/bmt-2015-0061.
7
Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications.用于生物医学应用的导电共轭聚合物包覆蓖麻蚕丝丝素蛋白纤维的制备与表征
Macromol Biosci. 2017 Jul;17(7). doi: 10.1002/mabi.201600443. Epub 2017 Feb 27.
8
Novel silk fibroin films prepared by formic acid/hydroxyapatite dissolution method.通过甲酸/羟基磷灰石溶解法制备的新型丝素蛋白膜。
Mater Sci Eng C Mater Biol Appl. 2014 Apr 1;37:48-53. doi: 10.1016/j.msec.2013.12.041. Epub 2014 Jan 3.
9
Influence of alcohol treatments on properties of silk-fibroin-based films for highly optically transparent coating applications.酒精处理对用于高光学透明涂层应用的丝素蛋白基薄膜性能的影响。
RSC Adv. 2020 Apr 21;10(27):15913-15923. doi: 10.1039/d0ra02634d.
10
Phosphorylation of silk fibroins improves the cytocompatibility of silk fibroin derived materials: a platform for the production of tuneable material.丝素蛋白的磷酸化改善了丝素蛋白衍生材料的细胞相容性：一种用于生产可调节材料的平台。
Biotechnol J. 2014 Oct;9(10):1267-78. doi: 10.1002/biot.201400302. Epub 2014 Aug 29.

引用本文的文献

1
Probing the Physicochemical, Nanomorphological, and Antimicrobial Attributes of Sustainable Silk Fibroin/Copaiba Oleoresin-Loaded PVA Films for Food Packaging Applications.探究用于食品包装应用的可持续丝素蛋白/柯巴脂油树脂负载聚乙烯醇薄膜的物理化学、纳米形态学及抗菌特性
Polymers (Basel). 2025 Jan 30;17(3):375. doi: 10.3390/polym17030375.

本文引用的文献

1
Broadband Multidimensional Spectroscopy Identifies the Amide II Vibrations in Silkworm Films.宽带多维光谱法鉴定家蚕丝膜中的酰胺 II 振动。
Molecules. 2022 Sep 23;27(19):6275. doi: 10.3390/molecules27196275.
2
Supertough and highly stretchable silk protein-based films with controlled biodegradability.具有可控生物降解性的超强韧和高可拉伸性丝蛋白基薄膜。
Acta Biomater. 2022 Nov;153:149-158. doi: 10.1016/j.actbio.2022.09.010. Epub 2022 Sep 12.
3
Influence of alcohol treatments on properties of silk-fibroin-based films for highly optically transparent coating applications.
酒精处理对用于高光学透明涂层应用的丝素蛋白基薄膜性能的影响。
RSC Adv. 2020 Apr 21;10(27):15913-15923. doi: 10.1039/d0ra02634d.
4
The trRosetta server for fast and accurate protein structure prediction.TrRosetta 服务器：用于快速准确的蛋白质结构预测。
Nat Protoc. 2021 Dec;16(12):5634-5651. doi: 10.1038/s41596-021-00628-9. Epub 2021 Nov 10.
5
The HDOCK server for integrated protein-protein docking.HDOCK 服务器：用于整合蛋白质-蛋白质对接
Nat Protoc. 2020 May;15(5):1829-1852. doi: 10.1038/s41596-020-0312-x. Epub 2020 Apr 8.
6
Hierarchical Structure of Silk Materials Versus Mechanical Performance and Mesoscopic Engineering Principles.丝材料的层次结构与力学性能及介观工程原理
Small. 2019 Dec;15(51):e1903948. doi: 10.1002/smll.201903948. Epub 2019 Oct 28.
7
Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation.表面活化法制备丝素蛋白膜涂层的 MgZnCa 合金，具有增强的体外和体内性能。
Acta Biomater. 2019 Jun;91:99-111. doi: 10.1016/j.actbio.2019.04.048. Epub 2019 Apr 24.
8
Thai silk fibroin gelation process enhancing by monohydric and polyhydric alcohols.一元醇和多元醇促进泰国丝素凝胶化过程。
Int J Biol Macromol. 2018 Oct 15;118(Pt B):1726-1735. doi: 10.1016/j.ijbiomac.2018.07.017. Epub 2018 Jul 11.
9
SWISS-MODEL: homology modelling of protein structures and complexes.SWISS-MODEL：蛋白质结构和复合物的同源建模。
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303. doi: 10.1093/nar/gky427.
10
Stability of UV/ozone-treated thermoplastics under different storage conditions for microfluidic analytical devices.用于微流控分析设备的紫外线/臭氧处理热塑性塑料在不同储存条件下的稳定性
RSC Adv. 2017 Jul 29;7(59):37374-37379. doi: 10.1039/c7ra07435b. Epub 2017 Jul 28.