School of Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Hanpu Science and Teaching Park, Changsha, 410208, Hunan, China.
Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, 300 Xueshi Road, Hanpu Science and Teaching Park, Changsha, 410208, Hunan, China.
J Transl Med. 2024 Jun 14;22(1):569. doi: 10.1186/s12967-024-05246-z.
Cancer remains a leading cause of mortality and poses a substantial threat to public health. Studies have revealed that Long noncoding RNA DANCR is a cytoplasmic lncRNA whose aberrant expression plays a pivotal role in various cancer types. Within tumour biology, DANCR exerts regulatory control over crucial processes such as proliferation, invasion, metastasis, angiogenesis, inflammatory responses, cellular energy metabolism reprogramming, and apoptosis. By acting as a competitive endogenous RNA for miRNAs and by interacting with proteins and mRNAs at the molecular level, DANCR contributes significantly to cancer progression. Elevated DANCR levels have also been linked to heightened resistance to anticancer drugs. Moreover, the detection of circulating DANCR holds promise as a valuable biomarker for aiding in the clinical differentiation of different cancer types. This article offers a comprehensive review and elucidation of the primary functions and molecular mechanisms through which DANCR influences tumours.
癌症仍然是主要的死亡原因，对公众健康构成重大威胁。研究表明，长非编码 RNA DANCR 是一种细胞质 lncRNA，其异常表达在各种癌症类型中起着关键作用。在肿瘤生物学中，DANCR 对增殖、侵袭、转移、血管生成、炎症反应、细胞能量代谢重编程和细胞凋亡等关键过程进行调节控制。DANCR 通过充当 miRNA 的竞争性内源性 RNA，并在分子水平上与蛋白质和 mRNAs 相互作用，对癌症的进展有重要贡献。DANCR 水平的升高也与抗癌药物的耐药性增加有关。此外，循环 DANCR 的检测有望成为一种有价值的生物标志物，有助于对不同类型的癌症进行临床区分。本文全面综述了 DANCR 影响肿瘤的主要功能和分子机制。
