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Impact of ALK inhibitors to potentiate ALK.CAR-T therapy in neuroblastoma.

作者信息

Bergaggio Elisa, Chiarle Roberto

机构信息

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy.

出版信息

Clin Transl Med. 2024 Jun;14(6):e1732. doi: 10.1002/ctm2.1732.

DOI:10.1002/ctm2.1732
PMID:38877641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11178513/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef47/11178513/7a0b0ad084b2/CTM2-14-e1732-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef47/11178513/7a0b0ad084b2/CTM2-14-e1732-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef47/11178513/7a0b0ad084b2/CTM2-14-e1732-g001.jpg

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2
ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells.间变性淋巴瘤激酶(ALK)抑制剂可增加ALK表达,并使神经母细胞瘤细胞对ALK嵌合抗原受体T细胞(CAR-T细胞)敏感。
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本文引用的文献

1
ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells.间变性淋巴瘤激酶(ALK)抑制剂可增加ALK表达,并使神经母细胞瘤细胞对ALK嵌合抗原受体T细胞(CAR-T细胞)敏感。
Cancer Cell. 2023 Dec 11;41(12):2100-2116.e10. doi: 10.1016/j.ccell.2023.11.004. Epub 2023 Nov 30.
2
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma.GD2-CART01 治疗复发/难治高危神经母细胞瘤。
N Engl J Med. 2023 Apr 6;388(14):1284-1295. doi: 10.1056/NEJMoa2210859.
3
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
ALK 驱动型难治/复发神经母细胞瘤中 lorlatinib 联合或不联合化疗的疗效:一项 I 期临床试验结果。
Nat Med. 2023 May;29(5):1092-1102. doi: 10.1038/s41591-023-02297-5. Epub 2023 Apr 3.
4
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma.一种针对 ALK 受体的抗体药物偶联物在神经母细胞瘤的临床前模型中显示出疗效。
Sci Transl Med. 2019 Mar 13;11(483). doi: 10.1126/scitranslmed.aau9732.
5
Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase.肿瘤抗原和受体密度调节靶向间变性淋巴瘤激酶的嵌合抗原受体的疗效。
Mol Ther. 2017 Sep 6;25(9):2189-2201. doi: 10.1016/j.ymthe.2017.06.008. Epub 2017 Jul 1.
6
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.ALK 受体酪氨酸激酶在人类癌症生物学中的作用机制研究。
Nat Rev Cancer. 2013 Oct;13(10):685-700. doi: 10.1038/nrc3580.
7
The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.ALK 突变体在 F1174 或 R1275 位置的组成性活性会损害受体运输。
Oncogene. 2011 Apr 28;30(17):2017-25. doi: 10.1038/onc.2010.595. Epub 2011 Jan 17.
8
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.神经母细胞瘤的荟萃分析显示,具有 MYCN 扩增的肿瘤中存在偏斜的 ALK 突变谱。
Clin Cancer Res. 2010 Sep 1;16(17):4353-62. doi: 10.1158/1078-0432.CCR-09-2660. Epub 2010 Aug 18.
9
Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients.预后不良的神经母细胞瘤患者中与突变无关的间变性淋巴瘤激酶过表达
Cancer Res. 2009 Sep 15;69(18):7338-46. doi: 10.1158/0008-5472.CAN-08-4419. Epub 2009 Sep 1.
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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.非霍奇金淋巴瘤中激酶基因ALK与核仁蛋白基因NPM的融合。
Science. 1994 Mar 4;263(5151):1281-4. doi: 10.1126/science.8122112.