Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, Suite 200, Boston, MA, 02114, USA.
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Arch Dermatol Res. 2024 Jun 15;316(7):390. doi: 10.1007/s00403-024-03148-0.
Calcinosis cutis is a condition that is commonly associated with autoimmune connective tissue diseases. It is characterized by the deposition of insoluble calcium salts in the skin and subcutaneous tissue, which can cause pain, impair function, and have significant impacts on quality of life. Calcinosis cutis is difficult to manage because there is no generally accepted treatment: evidence supporting treatments is mostly comprised of case reports and case series, sometimes yielding mixed findings. Both pharmacologic and procedural interventions have been proposed to improve calcinosis cutis, and each may be suited to different clinical scenarios. This review summarizes current treatment options for calcinosis cutis, with discussion of recommendations based on patient-specific factors and disease severity.
皮肤钙化病是一种常见于自身免疫性结缔组织疾病的病症。其特征是不溶性钙盐在皮肤和皮下组织中的沉积，可引起疼痛、功能障碍，并对生活质量产生重大影响。皮肤钙化病难以治疗，因为目前尚无被普遍接受的治疗方法：支持治疗的证据主要来自病例报告和病例系列，有时结果也不一致。已经提出了药物和程序干预措施来改善皮肤钙化病，每种方法可能适用于不同的临床情况。本综述总结了皮肤钙化病的当前治疗选择，并根据患者具体情况和疾病严重程度讨论了推荐建议。
