Ena P, Madeddu P, Glorioso N, Cerimele D, Rappelli A
Acta Cardiol. 1985;40(2):199-205.
We have observed a significant higher prevalence of essential hypertension, cardiovascular diseases and diabetes in a group of 100 psoriatic patients compared with sex and age matched hospitalized controls. Thirty-five psoriatic patients exhibited and enhanced plasma renin activity (PRA), while urinary aldosterone excretion was raised in 27% of the group. The autonomic responsiveness of psoriatic patients, studied by cold pressure test and tilting was normal; this finding supports the hypothesis that the enhanced activity of renin-angiotensin system is not due to an increased sympathetic function in these psoriatic patients. High values of cholesterol, triglycerides and depressed HDL-cholesterol concentrations were also observed. A complete clinical and laboratory examination is very useful in psoriasis in order to initiate an appropriate treatment of the risk factors whenever present.
我们观察到，与年龄和性别匹配的住院对照相比，100名银屑病患者中原发性高血压、心血管疾病和糖尿病的患病率显著更高。35名银屑病患者表现出血浆肾素活性（PRA）增强，而该组27%的患者尿醛固酮排泄增加。通过冷压试验和倾斜试验研究发现，银屑病患者的自主反应性正常；这一发现支持了肾素-血管紧张素系统活性增强并非由于这些银屑病患者交感神经功能增强的假说。还观察到胆固醇、甘油三酯值升高以及高密度脂蛋白胆固醇浓度降低。对于银屑病患者，进行全面的临床和实验室检查非常有用，以便在存在危险因素时启动适当的治疗。
