Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, USA.
Br J Pharmacol. 2019 Jun;176(12):1897-1913. doi: 10.1111/bph.14604. Epub 2019 Mar 18.
Patients with autoimmune rheumatic diseases including rheumatoid arthritis and systemic lupus erythematosus have an increased prevalence of hypertension. There is now a large body of evidence showing that the immune system is a key mediator in both human primary hypertension and experimental models. Many of the proposed immunological mechanisms leading to primary hypertension are paralleled in autoimmune rheumatic disorders. Therefore, examining the link between autoimmunity and hypertension can be informative for understanding primary hypertension. This review examines the prevalent hypertension, the immune mediators that contribute to the prevalent hypertension and their impact on renal function and how the risk of hypertension is potentially influenced by common hormonal changes that are associated with autoimmune rheumatic diseases. LINKED ARTICLES: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
患有自身免疫性风湿病（包括类风湿关节炎和系统性红斑狼疮）的患者高血压患病率增加。现在有大量证据表明，免疫系统是人类原发性高血压和实验模型中的关键介质。许多导致原发性高血压的拟议免疫机制在自身免疫性风湿病中是相似的。因此，检查自身免疫与高血压之间的联系有助于了解原发性高血压。这篇综述检查了常见的高血压、导致高血压的免疫介质及其对肾功能的影响，以及与自身免疫性风湿病相关的常见激素变化如何潜在地影响高血压的风险。
本文是免疫靶点在高血压中的一个专题部分的一部分。要查看该部分中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
