Kawaoi A, Tsuneda M
Acta Endocrinol (Copenh). 1985 Apr;108(4):518-24. doi: 10.1530/acta.0.1080518.
Immunohistochemical detection of T4, T3 and thyroglobulin (Tg) was undertaken in foetal and neonatal rat thyroid glands in an attempt to elucidate the functional development and maturation of the gland during these periods. Immunoreactive Tg first appeared in the cytoplasm of the immature thyroid epithelium on the 15th day of gestation, followed by the occurrence of T4 and T3 in the lumen of primitive follicles of the thyroid gland 2 days later. The stainability of Tg, T4 and T3 increased as the follicular structure became mature; however, no significant difference in staining patterns was observed during the perinatal periods.
为了阐明胎鼠和新生鼠甲状腺在这些时期的功能发育和成熟过程，对其甲状腺进行了T4、T3和甲状腺球蛋白（Tg）的免疫组化检测。免疫反应性Tg最早在妊娠第15天出现在未成熟甲状腺上皮细胞的细胞质中，2天后甲状腺原始滤泡腔中出现T4和T3。随着滤泡结构成熟，Tg、T4和T3的染色性增强；然而，围产期各阶段的染色模式未观察到显著差异。
