Department of Orthopaedics, Xinqiao Hospital, Army Medical University, No. 183, Xinqiao Street, Shapingba District, Chongqing 400037, China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Songjiang, Shanghai 201600, PR China.
Department of Health Management, Characteristic Medical Center of Chinese People's Armed Police Force, 220 Chenglin Road, Hedong District, Tianjin, China.
J Colloid Interface Sci. 2024 Nov;673:411-425. doi: 10.1016/j.jcis.2024.06.098. Epub 2024 Jun 13.
Multifunctional bioactive biomaterials with integrated bone and soft tissue regenerability hold great promise for the regeneration of trauma-affected skin and bone defects. The aim of this research was to fabricate aerogel scaffolds (GD-BF) by blending the appropriate proportions of short bioactive glass fiber (BGF), gelatin (Gel), and dopamine (DA). Electrospun polyvinyl pyrrolidone (PVP)-BGF fibers were converted into short BGF through calcination and homogenization. Microporous GD-BF scaffolds displayed good elastic deformation recovery and promoted neo-tissue formation. The DA could enable thermal crosslinking and enhance the mechanical properties and structural stability of the GD-BF scaffolds. The BGF-mediated release of therapeutic ions shorten hemostatic time (<30 s) in a rat tail amputation model and a rabbit artery injury model alongside inducing the regeneration of skin appendages (e.g., blood vessels, glands, etc.) in a full-thickness excisional defect model in rats (percentage wound closure: GD-BF2, 98 % vs. control group, 83 %) at day 14 in vitro. Taken together, these aerogel scaffolds may have significant promise for soft and hard tissue repair, which may also be worthy for the other related disciplines.
具有骨和软组织再生整合能力的多功能生物活性生物材料有望再生创伤性皮肤和骨缺损。本研究旨在通过混合适当比例的短生物活性玻璃纤维（BGF）、明胶（Gel）和多巴胺（DA）来制备气凝胶支架（GD-BF）。将静电纺丝的聚乙烯吡咯烷酮（PVP）-BGF 纤维通过煅烧和均化转化为短 BGF。微孔 GD-BF 支架具有良好的弹性变形恢复能力，并促进新组织形成。DA 可实现热交联，并增强 GD-BF 支架的机械性能和结构稳定性。BGF 介导的治疗离子释放可缩短大鼠尾切断模型和兔动脉损伤模型中的止血时间（<30s），并在大鼠全层切除缺陷模型中诱导皮肤附属物（如血管、腺体等）的再生（闭合百分比：GD-BF2，98%比对照组，83%），第 14 天体外。综上所述，这些气凝胶支架可能在软组织和硬组织修复方面具有重要的应用前景，这可能也值得其他相关学科研究。
