Yuan Zhengchao, Wu Siyuan, Fu Liwen, Wang Xinyi, Wang Zewen, Shafiq Muhammad, Feng Hao, Han Lu, Song Jiahui, El-Newehy Mohamed, Abdulhameed Meera Moydeen, Xu Yuan, Mo Xiumei, Jiang Shichao
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, 201620, Shanghai, PR China.
Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China.
Bioact Mater. 2025 Feb 13;47:513-527. doi: 10.1016/j.bioactmat.2025.01.030. eCollection 2025 May.
Slugs could secrete mucus with multifunctional characteristics, such as reversible gelation, mucoadhesiveness, and viscoelasticity, which can be harnessed for multifaceted biotechnological and healthcare applications. The dried mucus (DM) was prepared using slug, which can be adhered to the tissue surface through different types of interactions (lap-shear force, 1.1 N for DM-3 group). The DM-3 further exhibited the highest hemostatic ability as discerned in a liver trauma injury model (hemostasis time, <15 s), biocompatibility and biodegradability (an insignificant residue at 4 weeks) , and considerably improved skin repair in full-thickness excisional wounds (wound closure, 96.2 % at day 14). Taken together, slug's mucus can be easily prepared with an economic and an eco-friendly method, which may have broad biotechnological and healthcare implications and potential utility in other related disciplines. This transition from natural components to the biomaterial may provide an invaluable platform for different types of applications.
蛞蝓能够分泌具有多种功能特性的黏液，如可逆凝胶化、黏膜黏附性和黏弹性，这些特性可用于多方面的生物技术和医疗保健应用。利用蛞蝓制备了干燥黏液（DM），其可通过不同类型的相互作用（搭接剪切力，DM-3组为1.1 N）附着于组织表面。在肝创伤损伤模型中，DM-3表现出最高的止血能力（止血时间，<15秒）、生物相容性和生物降解性（4周时残留量不显著），并显著促进了全层切除伤口的皮肤修复（第14天伤口闭合率为96.2%）。综上所述，蛞蝓黏液可以通过经济且环保的方法轻松制备，这可能在生物技术和医疗保健领域具有广泛的意义，并在其他相关学科中具有潜在用途。这种从天然成分到生物材料的转变可能为不同类型的应用提供一个宝贵的平台。
