通过表面增强拉曼散射对口罩上的SARS-CoV-2相关物质进行检测
On-mask detection of SARS-CoV-2 related substances by surface enhanced Raman scattering.
作者信息
Liu Xiaohu, Xie Ruifeng, Li Kang, Zhu Zhelei, Huang Xi, He Qian, Sun Zhe, He Haiyang, Ge Yuancai, Zhang Qingwen, Chen Hu, Wang Yi
机构信息
National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Xueyuan Road 270, Wenzhou, 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Jinlian Road 1, Wenzhou, 325001, China.
School of Optoelectronic Engineering, Changchun University of Science and Technology, Weixing Road 7089, Changchun, 130013, China.
出版信息
Talanta. 2024 Sep 1;277:126403. doi: 10.1016/j.talanta.2024.126403. Epub 2024 Jun 10.
We have developed a convenient surface-enhanced Raman scattering (SERS) platform based on vertical standing gold nanowires (v-AuNWs) which enabled the on-mask detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related substances such as the Spike-1 protein and the corresponding pseudo-virus. The Spike-1 protein was clearly distinguished from BSA protein with an accuracy above 99 %, and the detection limit could be achieved down to 0.01 μg/mL. Notably, a similar accuracy was achieved for the pseudo-SARS-CoV-2 (pSARS-2) virus as compared to the pseudo-influenza H7N9 (pH7N9) virus. The sensing strategy and setups could be easily adapted to the real SARS-CoV-2 virus and other highly contagious viruses. It provided a promising way to screen the virus carriers by a fast evaluation of their wearing v-AuNWs integrated face-mask which was mandatory during the pandemic.
我们基于垂直站立的金纳米线（v-AuNWs）开发了一种便捷的表面增强拉曼散射（SERS）平台，该平台能够在口罩上检测严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关物质，如刺突1蛋白（Spike-1）和相应的假病毒。Spike-1蛋白与牛血清白蛋白（BSA）蛋白能够清晰区分，准确率超过99%，检测限可达0.01μg/mL。值得注意的是，与甲型流感病毒H7N9（pH7N9）假病毒相比，该平台对SARS-CoV-2假病毒（pSARS-2）也能达到相似的准确率。这种传感策略和装置能够轻松应用于实际的SARS-CoV-2病毒以及其他高传染性病毒。它为通过快速评估佩戴集成v-AuNWs的口罩（这在疫情期间是强制性的）来筛查病毒携带者提供了一种很有前景的方法。
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