Teixeira Antonio L, Almeida Osvaldo P, Lavin Paola, Barbosa Izabela G, Alda Martin, Altinbas Kursat, Balanzá-Martínez Vicent, Briggs Farren B S, Calkin Cynthia, Chen Peijun, Dols Annemieke, Eyler Lisa T, Forester Brent P, Forlenza Orestes V, Gildengers Ariel G, Hajek Tomas, Haarman Benno, Korten Nicole, Jimenez Esther, Lafer Beny, Levin Jennifer B, Montejo Laura, Nunes Paula V, Olagunju Andrew T, Oluwaniyi Stephen, Oudega Mardien L, Patrick Regan E, Radua Joaquim, Rej Soham, Schouws Sigfried, Soares Jair C, Sutherland Ashley N, Vieta Eduard, Yala Joy, Sajatovic Martha
Biggs Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Faculdade Santa Casa BH, Belo Horizonte, Brazil.
Medical School, University of Western Australia, Perth, Australia.
Gen Hosp Psychiatry. 2024 Sep-Oct;90:6-11. doi: 10.1016/j.genhosppsych.2024.06.004. Epub 2024 Jun 12.
To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.
OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).
After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.
This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.
比较老年双相情感障碍患者（OABD）与非精神科对照者（NC）的躯体疾病患病率，并分析患病率的性别差异。
OABD定义为年龄≥50岁的成年人中的双相情感障碍。分析的结局指标是影响心血管、呼吸、胃肠、泌尿生殖、肾脏、肌肉骨骼和内分泌系统疾病的患病率。该分析使用了来自全球双相情感障碍协作性衰老与老年实验（GAGE-BD）数据集的OABD参与者（n = 878；平均年龄60.9±8.0岁，n = 496（56%）为女性）的横断面数据，以及在相同地点招募的NC参与者（n = 355；平均年龄64.4±9.7岁，n = 215（61%）为女性）。
在控制性别、年龄、教育程度和吸烟史后，OABD组比NC组有更多的心血管疾病（优势比[95%置信区间]：2.12[1.38 - 3.30]）、肾脏疾病（5.97[1.31 - 43.16]）、肌肉骨骼疾病（2.09[1.30 - 3.43]）和内分泌疾病（1.90[1.20 - 3.05]）。在控制年龄、教育程度、吸烟史和研究地点后，患有OABD的女性比患有OABD的男性有更多的胃肠疾病（1.56[0.99 - 2.49]）、泌尿生殖疾病（1.72[1.02 - 2.92]）、肌肉骨骼疾病（2.64[1.66 - 4.37]）和内分泌疾病（1.71[1.08 - 2.73]）。
这项GAGE-BD重复研究证实了先前的研究结果，即OABD患者比匹配的对照参与者有更多的躯体疾病患病率，并且这种健康负担在女性中显著更大。
