Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, PR China.
The State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, the Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, PR China.
Biomed Pharmacother. 2024 Jul;176:116904. doi: 10.1016/j.biopha.2024.116904. Epub 2024 Jun 14.
Globally, cancer is a serious health problem. It is unfortunate that current anti-cancer strategies are insufficiently specific and damage the normal tissues. There's urgent need for development of new anti-cancer strategies. More recently, increasing attention has been paid to the new application of ferroptosis and nano materials in cancer research. Ferroptosis, a condition characterized by excessive reactive oxygen species-induced lipid peroxidation, as a new programmed cell death mode, exists in the process of a number of diseases, including cancers, neurodegenerative disease, cerebral hemorrhage, liver disease, and renal failure. There is growing evidence that inducing ferroptosis has proven to be an effective strategy against a variety of chemo-resistant cancer cells. Nano-drug delivery system based on nanotechnology provides a highly promising platform with the benefits of precise control of drug release and reduced toxicity and side effects. This paper reviews the latest advances of combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics. Given the new chances and challenges in this emerging area, we need more attention to the combination of nanotechnology and ferroptosis in the treatment of cancer in the future.
全球范围内，癌症是一个严重的健康问题。不幸的是，目前的抗癌策略不够特异，会损伤正常组织。因此，迫切需要开发新的抗癌策略。最近，人们越来越关注铁死亡和纳米材料在癌症研究中的新应用。铁死亡是一种由过量的活性氧诱导的脂质过氧化引起的新型程序性细胞死亡模式，存在于包括癌症、神经退行性疾病、脑出血、肝病和肾衰竭在内的多种疾病的过程中。越来越多的证据表明，诱导铁死亡已被证明是对抗多种化疗耐药癌细胞的有效策略。基于纳米技术的纳米药物递送系统提供了一个极具前景的平台，具有精确控制药物释放和降低毒性和副作用的优点。本文综述了基于生物医学纳米技术诱导铁死亡的联合治疗策略在癌症治疗中的最新进展。鉴于该新兴领域的新机遇和挑战，我们需要在未来更多地关注纳米技术和铁死亡在癌症治疗中的结合。
