Department of Pharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, 350108, PR China.
Department of Pharmacy, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen, 518001, PR China.
Eur J Pharmacol. 2020 Aug 5;880:173198. doi: 10.1016/j.ejphar.2020.173198. Epub 2020 May 27.
Ferroptosis is a new iron and reactive oxygen species dependent programmed cell death process which is different from apoptosis, necrosis, and autophagy. It is closely related to a number of disease progression including cancers, neurodegenerative disease, cerebral hemorrhage, liver disease, and renal failure. The development of different ferroptotic inducers has been proved as an efficient therapeutic strategy for a variety of chemoradiotherapy-resistant cancer cells and cancer stem cells. In addition, the development of ferroptotic inhibitors is also becoming an emerging research hotspot for the treatment of many non-cancerous diseases. Furthermore, the combination of nanotechnology with ferroptotic therapies has exhibited additional advantages such as enhanced targeting and/or stimuli-responsive ability to tumor microenvironment, ameliorated drug solubility, ease of preparation and the integration of multifunctional theranostic platforms to develop synergetic combined therapies of great clinical importance. This paper reviews the latest advances of using tailored ferroptotic nanoparticles and ferroptotic molecular probes to be relevant for the accurate diagnosis and treatment of different diseases. Finally, the opportunities and challenges of this burgeoning field were spotlighted to promote the rational design of nano-ferroptotic drugs or theranostic probes in the near future.
铁死亡是一种新的铁依赖性和活性氧依赖的程序性细胞死亡过程，与细胞凋亡、坏死和自噬不同。它与许多疾病的进展密切相关，包括癌症、神经退行性疾病、脑出血、肝病和肾衰竭。不同铁死亡诱导剂的开发已被证明是一种有效的治疗策略，可用于多种化疗和放疗耐药的癌细胞和癌症干细胞。此外，铁死亡抑制剂的开发也正在成为治疗许多非癌症疾病的新兴研究热点。此外，纳米技术与铁死亡疗法的结合显示出了额外的优势，例如增强对肿瘤微环境的靶向性和/或刺激响应能力、改善药物溶解度、易于制备以及整合多功能治疗诊断平台，以开发具有重要临床意义的协同联合治疗。本文综述了使用定制的铁死亡纳米颗粒和铁死亡分子探针在不同疾病的准确诊断和治疗中的最新进展。最后，强调了这个新兴领域的机遇和挑战，以促进在不久的将来合理设计纳米铁死亡药物或治疗诊断探针。
