特定饮食模式、肠道微生物群组成与中国年轻成年人亚临床抑郁发生的相关性。

Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults.

机构信息

Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; South China Research Center for Acupuncture and Moxibustion, Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China; South China Research Center for Acupuncture and Moxibustion, Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

J Adv Res. 2024 Nov;65:183-195. doi: 10.1016/j.jare.2024.05.030. Epub 2024 Jun 13.

DOI:10.1016/j.jare.2024.05.030

PMID:38879123

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11518947/

Abstract

INTRODUCTION

The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood.

OBJECTIVES

This study sought to understand the dietary habits, gut microbiota composition, etc. among individuals with SD in young adults and to investigate their association with SD occurrence.

METHODS

Employing a cross-sectional approach, 178 individuals with SD, aged 18-32 years, were matched with 114 healthy counterparts. SD status was evaluated using the Zung Self-rating Depression Scale (SDS), Zung Self-rating Anxiety Scale (SAS), Beck Depression Inventory 2nd version (BDI-II), the 17-item Hamilton Rating Scales of Depression (HAMD-17), and Pittsburgh Sleep Quality Index (PSQI). Metagenomic sequencing was utilized to identify fecal microbial profiles. Dietary patterns were discerned via factor analysis of a 25-item food frequency questionnaire (FFQ). Logistic regression analysis and mediation analysis were performed to explore the potential links between gut microbiota, dietary patterns, and incident SD.

RESULTS

Data on dietary habits were available for 292 participants (mean [SD] age, 22.1 [2.9] years; 216 [73.9 %] female). Logistic regression analysis revealed that dietary patterns Ⅰ (odds ratio [OR], 0.34; 95 % CI, 0.15-0.75) and IV (OR, 0.39; 95 % CI, 0.17-0.86 and OR, 0.39; 95 % CI, 0.18-0.84) were associated with reduced risk of SD. Distinct microbial profiles were observed in young adults with SD, marked by increased microbial diversity and taxonomic alterations. Moreover, mediation analysis suggested Veillonella atypica as a potential mediator linking SDS or BDI-II scores with a healthy dietary pattern rich in bean products, coarse grains, nuts, fruits, mushrooms, and potatoes (β = 0.25, 95 % CI: 0.02-0.78 and β = 0.18, 95 % CI: 0.01-0.54).

CONCLUSIONS

Our findings highlight the complex interplay between dietary patterns, gut microbiota, and the risk of developing SD in young adults, underscoring the potential for dietary interventions and microbiome modulation in mental health promotion.

摘要

简介

影响因素与青年亚临床抑郁（SD）发病率之间的相互作用仍知之甚少。

目的

本研究旨在了解青年 SD 患者的饮食习惯、肠道微生物群落组成等，并探讨其与 SD 发生的关系。

方法

采用横断面研究方法，选择 178 名年龄在 18-32 岁的 SD 患者，并与 114 名健康对照者进行匹配。SD 状态采用zung 自评抑郁量表（SDS）、zung 自评焦虑量表（SAS）、贝克抑郁量表第二版（BDI-II）、17 项汉密尔顿抑郁量表（HAMD-17）和匹兹堡睡眠质量指数（PSQI）进行评估。采用宏基因组测序技术鉴定粪便微生物谱。通过对 25 项食物频率问卷（FFQ）的因子分析来识别饮食模式。采用 logistic 回归分析和中介分析探讨肠道微生物群、饮食模式与新发 SD 之间的潜在联系。

结果

共有 292 名参与者（平均[SD]年龄 22.1[2.9]岁；216[73.9%]为女性）提供了饮食习惯数据。logistic 回归分析显示，饮食模式Ⅰ（比值比[OR]，0.34；95%CI，0.15-0.75）和 IV（OR，0.39；95%CI，0.17-0.86 和 OR，0.39；95%CI，0.18-0.84）与 SD 风险降低相关。SD 青年的肠道微生物群特征明显，微生物多样性增加，分类组成发生改变。此外，中介分析表明韦荣球菌属（Veillonella atypica）可能是将 SDS 或 BDI-II 评分与富含豆类、粗粮、坚果、水果、蘑菇和土豆的健康饮食模式联系起来的潜在中介物（β=0.25，95%CI：0.02-0.78 和 β=0.18，95%CI：0.01-0.54）。