Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
Med Oncol. 2024 Jun 15;41(7):176. doi: 10.1007/s12032-024-02424-3.
Asparagine is a non-essential amino acid crucial for protein biosynthesis and function, and therefore cell maintenance and growth. Furthermore, this amino acid has an important role in regulating several metabolic pathways, such as tricarboxylic acid cycle and the urea cycle. When compared to normal cells, tumor cells typically present a higher demand for asparagine, making it a compelling target for therapy. In this review article, we investigate different facets of asparagine bioavailability intricate role in malignant tumors raised from solid organs. We take a comprehensive look at asparagine synthetase expression and regulation in cancer, including the impact on tumor growth and metastasis. Moreover, we explore asparagine depletion through L-asparaginase as a potential therapeutic method for aggressive solid tumors, approaching different formulations of the enzyme and combinatory therapies. In summary, here we delve into studies about endogenous and exogenous asparagine availability in solid cancers, analyzing therapeutic implications and future challenges.
天冬酰胺是一种非必需氨基酸，对蛋白质生物合成和功能至关重要，因此对细胞维持和生长也很重要。此外，这种氨基酸在调节几种代谢途径方面也起着重要作用，如三羧酸循环和尿素循环。与正常细胞相比，肿瘤细胞通常对天冬酰胺的需求更高，使其成为治疗的一个有吸引力的靶点。在这篇综述文章中，我们研究了来自实体器官的恶性肿瘤中天冬酰胺生物利用度的不同方面及其复杂作用。我们全面研究了天冬酰胺合成酶在癌症中的表达和调节，包括对肿瘤生长和转移的影响。此外，我们还探讨了通过 L-天冬酰胺酶消耗天冬酰胺作为治疗侵袭性实体肿瘤的潜在方法，涉及不同形式的酶和联合治疗。总之，我们深入研究了实体癌中天冬酰胺内源性和外源性可用性的研究，分析了治疗意义和未来的挑战。
