Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Curr Pharm Des. 2024;30(32):2550-2561. doi: 10.2174/0113816128330298240708110336.
Psoriasis (Pso) is an autoimmune inflammatory skin disease characterized by red plaques covered in silver scales. The existing treatments provide limited benefits and are associated with certain drawbacks which limit their use. Thus, there is a need to explore more options that are highly target-specific and associated with minimal side effects. Researchers have thoroughly investigated the use of herbal drugs for their therapeutic potential. Preclinical studies demonstrate that phytochemicals such as curcumin, psoralen, and dithranol have antipsoriatic effects. These phytoconstituents inhibit the signalling pathways, such as the interleukin (IL) 23/Th17 axis and IL-36 inflammatory loop involved in the pathogenesis of Pso. These phytoconstituents down-regulate the pro-inflammatory cytokines like IL-17 and tumor necrosis factor (TNF)-α. However, their application in clinical settings is limited due to poor bioavailability and access to target sites. Combining phytoconstituents with modern delivery platforms like nanocarriers can address these shortcomings and improve therapeutic efficacy. This review explores the potential of herbal remedies as a substitute for conventional therapies, emphasizing the clinical trials conducted with these herbal medicines. The paper is supported by the discussion on nanocarriers like liposomes, niosomes, emulsomes, ethosomes, nanostructured lipid carriers, nanoemulsions, and dendrimers that are used to deliver herbal medicines.
银屑病（Pso）是一种自身免疫性炎症性皮肤病，其特征是红色斑块上覆盖着银色鳞屑。现有的治疗方法提供的益处有限，并且存在某些缺点，限制了它们的使用。因此，需要探索更多高度靶向特异性且副作用最小的选择。研究人员已经彻底研究了草药药物的治疗潜力。临床前研究表明，姜黄素、补骨脂素和蒽林等植物化学物质具有抗银屑病作用。这些植物成分抑制信号通路，如参与 Pso 发病机制的白细胞介素 (IL) 23/Th17 轴和 IL-36 炎症环。这些植物成分下调促炎细胞因子，如 IL-17 和肿瘤坏死因子 (TNF)-α。然而，由于生物利用度差和难以到达靶位，它们在临床环境中的应用受到限制。将植物成分与现代递药平台（如纳米载体）结合使用可以解决这些缺点并提高治疗效果。这篇综述探讨了草药作为传统疗法替代品的潜力，强调了这些草药药物的临床试验。本文通过讨论脂质体、非离子型脂质体、乳化脂质体、醇质体、纳米结构脂质载体、纳米乳剂和树枝状大分子等纳米载体来支持这篇论文，这些载体用于输送草药药物。
