Dong Qi, Dai Gaoying, Quan Nanhu, Tong Qian
Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, 130021, China.
Mol Cell Biochem. 2025 Feb;480(2):733-745. doi: 10.1007/s11010-024-05048-3. Epub 2024 Jun 16.
As the world's aging population increases, cardiovascular diseases (CVDs) associated with aging deserve increasing attention. CVD in association with age is considered a major cause of morbidity and mortality worldwide. In this review, we provide an overview of the key molecular pathways, cellular processes such as autophagy, oxidative stress, inflammatory responses, myocardial remodeling and ischemia-refocused injury that accompany CVD as well as the natural products of targeting these mechanisms and some of the dietary habits that have been studied in cardiovascular-related diseases. The potential preventive and therapeutic avenues resulting from these dietary habits and natural products related to animal models and clinical studies can help us to better understand the processes involved in cardiovascular diseases and provide recommendations to reduce the cardiovascular burden associated with aging heart.
随着全球老龄化人口的增加，与衰老相关的心血管疾病（CVDs）值得越来越多的关注。与年龄相关的心血管疾病被认为是全球发病和死亡的主要原因。在本综述中，我们概述了伴随心血管疾病的关键分子途径、细胞过程，如自噬、氧化应激、炎症反应、心肌重塑和缺血再灌注损伤，以及针对这些机制的天然产物和一些在心血管相关疾病中已被研究的饮食习惯。这些与动物模型和临床研究相关的饮食习惯和天然产物所带来的潜在预防和治疗途径，有助于我们更好地理解心血管疾病所涉及的过程，并为减轻与衰老心脏相关的心血管负担提供建议。
