Department of Neurology, Deyang People's Hospital, Deyang, China.
Department of Neurology, Deyang People's Hospital, Deyang, China.
Clin Neurol Neurosurg. 2024 Aug;243:108391. doi: 10.1016/j.clineuro.2024.108391. Epub 2024 Jun 13.
To estimate the incidence of stroke and determine the role that risk factors play in the high-risk stroke populace in southwest China.
This research employed a prospective cohort design that focused on the community. Eight communities in southwest China were selected randomly for this study. The residents aged 40 years and older who volunteered to participate were surveyed through face-to-face interviews. Those with a history of stroke or at least three of the eight stroke-related risk factors were categorized as the high-risk stroke population. A total of 2698 high-risk individuals were included in the study after a 4.7-year follow-up period. The incidence of stroke and the association between risk variables and stroke occurrence were estimated.
During 4.7-year follow-up, the incidence of total stroke, ischemic stroke, and hemorrhagic stroke in high-risk stroke population were 5.0 %, 4.4 % and 0.9 % respectively. It should be noted that some participants experienced both cerebral infarction and cerebral hemorrhage during the follow-up period. The multivariate analytic model revealed that a personal history of stroke (OR=3.397, 95 % CI 2.365-4.878, p<.001) was substantially linked with an elevated risk of overall stroke. This correlation remained consistent for both ischemic and hemorrhagic stroke.
This study revealed a high prevalence and incidence of stroke among a high-risk group in southwestern China. Furthermore, it demonstrated that individuals with a personal history of stroke are at an elevated risk of future stroke, suggesting the need for additional precautions in this population.
评估中国西南部高危卒中人群的卒中发生率，并确定危险因素的作用。
本研究采用前瞻性队列设计，以社区为基础。随机选择中国西南部的 8 个社区进行此项研究。通过面对面访谈对自愿参与的 40 岁及以上居民进行调查。有卒中史或至少有 8 种卒中相关危险因素中的 3 种的患者被归类为高危卒中人群。在 4.7 年的随访后，共有 2698 名高危个体纳入研究。估计了卒中的发生率以及风险变量与卒中发生之间的关系。
在 4.7 年的随访期间，高危卒中人群的总卒中、缺血性卒中和出血性卒中的发生率分别为 5.0%、4.4%和 0.9%。需要注意的是，一些参与者在随访期间同时发生了脑梗死和脑出血。多变量分析模型显示，既往卒中史（OR=3.397，95%CI 2.365-4.878，p<.001）与总体卒中风险显著相关。这种相关性在缺血性卒中和出血性卒中中均一致。
本研究揭示了中国西南部高危人群中卒中的高患病率和高发生率。此外，研究表明既往有卒中史的个体未来发生卒中的风险增加，提示该人群需要采取额外的预防措施。
