Shulman D, Beardsmore C S, Aronson H B, Godfrey S
Anesthesiology. 1985 May;62(5):551-6. doi: 10.1097/00000542-198505000-00001.
The effect of ketamine on the functional residual capacity (FRC) was measured in nine ASA class I children prior to elective surgery. FRC was determined by the closed-circuit helium dilution method on the day prior to surgery in the awake state and also following induction of anesthesia on the day of the operation. Anesthesia consisted of ketamine by continuous intravenous infusion following preanesthetic sedation with atropine and triclofos or flunitrazepam. There were no significant differences in FRC between the measurements in the awake state and anesthetized (392 +/- 43 SEM ml, and 411 +/- 53 SEM ml, respectively), and the authors conclude that ketamine does not affect resting lung volume in young children.
在9名择期手术前的美国麻醉医师协会（ASA）I级儿童中，测量了氯胺酮对功能残气量（FRC）的影响。FRC在手术前一天清醒状态下通过闭合回路氦稀释法测定，并且在手术当天麻醉诱导后也进行了测定。麻醉方法为在使用阿托品和三氯福司或氟硝西泮进行麻醉前镇静后，持续静脉输注氯胺酮。清醒状态下和麻醉状态下的FRC测量值之间无显著差异（分别为392±43 SEM毫升和411±53 SEM毫升），作者得出结论，氯胺酮不影响幼儿的静息肺容量。
