Testa N G, Hendry J H, Molineux G
Anticancer Res. 1985 Jan-Feb;5(1):101-10.
Long-term bone marrow damage, characterised by stem, progenitor and stromal cell abnormalities is a frequent occurrence after cytotoxic treatments. The relative contributions of each of these components are difficult to analyse, especially in the case of patients who have received combined chemotherapy. The damage may be latent, and not manifested in low numbers of mature functional cells in the blood, but may become apparent as an hypoplastic syndrome at later times. Little tendency of recovery to normal parameters is seen in experimental animals and in patients.
长期骨髓损伤，其特征为干细胞、祖细胞和基质细胞异常，在细胞毒性治疗后经常出现。这些成分各自的相对作用难以分析，尤其是在接受联合化疗的患者中。这种损伤可能是潜伏性的，在血液中成熟功能细胞数量较少时未表现出来，但在以后可能会表现为发育不全综合征。在实验动物和患者中很少见到恢复到正常参数的趋势。
