Yamada Yuta, Furukawa Kenei, Haruki Koichiro, Okui Norimitsu, Shirai Yoshihiro, Tsunematsu Masashi, Yanagaki Mitsuru, Yasuda Jungo, Onda Shinji, Ikegami Toru
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-Ku, Tokyo, 105-8461, Japan.
Surg Today. 2025 Jan;55(1):70-77. doi: 10.1007/s00595-024-02882-2. Epub 2024 Jun 16.
Atherosclerosis and cancer may progress through common pathological factors. This study was performed to investigate the association between the abdominal aortic calcification (AAC) volume and outcomes following surgical treatment for pancreatic cancer.
The subjects of this retrospective study were 194 patients who underwent pancreatic cancer surgery between 2007 and 2020. The AAC volume was assessed through routine preoperative computed tomography. Univariate and multivariate analyses were performed to evaluate the impact of the AAC volume on oncological outcomes.
A higher AAC volume (≥ 312 mm) was identified in 66 (34%) patients, who were significantly older and had a higher prevalence of diabetes and sarcopenia. Univariate analysis revealed several risk factors for overall survival (OS), including male sex, an AAC volume ≥ 312 mm3, elevated carbohydrate antigen 19-9, prolonged operation time, increased intraoperative bleeding, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy. Multivariate analysis identified an AAC volume ≥ 312 mm3, prolonged operation time, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy as independent OS risk factors. The OS rate was significantly lower in the high AAC group than in the low AAC group.
The AAC volume may serve as a preoperative prognostic indicator for patients with pancreatic cancer.
动脉粥样硬化和癌症可能通过共同的病理因素进展。本研究旨在探讨腹主动脉钙化（AAC）体积与胰腺癌手术治疗后预后之间的关联。
本回顾性研究的对象为2007年至2020年间接受胰腺癌手术的194例患者。通过术前常规计算机断层扫描评估AAC体积。进行单因素和多因素分析以评估AAC体积对肿瘤学预后的影响。
66例（34%）患者的AAC体积较高（≥312立方毫米），这些患者年龄显著更大，糖尿病和肌肉减少症的患病率更高。单因素分析显示了几个总生存期（OS）的危险因素，包括男性、AAC体积≥312立方毫米、糖类抗原19-9升高、手术时间延长、术中出血增加、淋巴结转移、低分化以及未进行辅助化疗。多因素分析确定AAC体积≥312立方毫米、手术时间延长、淋巴结转移、低分化以及未进行辅助化疗为独立的OS危险因素。高AAC组的OS率显著低于低AAC组。
AAC体积可能作为胰腺癌患者的术前预后指标。
