M Yogesh, Patel Monika G, Makwana Hardik Harshadbhai, Kalariya Hardikkumar
Department of Community Medicine, M P Shah Government Medical College, New PG Hostel, Shri MP Shah Medical College campus, GG Hospital, Patel Colony Post, Jamnagar, Gujarat, 361008, India.
Department of Pathology, GMERS Medical College, Junagadh, Gujarat, India.
Clin Diabetes Endocrinol. 2024 Jun 17;10(1):22. doi: 10.1186/s40842-024-00179-4.
Sarcopenia and sarcopenic obesity are growing concerns associated with increasing diabetes incidence, but data from Indian diabetic cohorts are limited. This study examined the prevalence and clinical factors associated with sarcopenia and sarcopenic obesity.
In this cross-sectional study, 750 participants aged 35-70 years were recruited by systematic stratification and a fixed quota sampling technique from medical camps and categorized into diabetic (n = 250), nondiabetic (n = 250), and obese nondiabetic (n = 250) groups. The assessments included questionnaires, muscle mass estimation by bioimpedance analysis, and blood tests. Sarcopenia was defined using the Asian Working Group consensus, and sarcopenic obesity was defined as sarcopenia with a BMI ≥ 25 kg/m2. Logistic regression was used to analyze risk factors.
Sarcopenia affected 60% of diabetic patients, 28% of nondiabetic patients, and 38% of nonobese nondiabetic patients (p < 0.001). The prevalence of sarcopenic obesity was 40%, 11%, and 30%, respectively (p < 0.001). Diabetes was associated with 2.3-fold greater odds (95% CI 1.1-4.7) of sarcopenia and 2.4-fold greater odds (1.1-5.0) of sarcopenic obesity after adjustment. A duration greater than 10 years, uncontrolled diabetes, age greater than 65 years, low physical activity, hypertension, and dyslipidemia also independently increased the odds.
Indian adults with type 2 diabetes have a high burden of sarcopenia and sarcopenic obesity. Early optimization of diabetes care and lifestyle changes are vital for preserving muscle health.
肌肉减少症和肌肉减少性肥胖与糖尿病发病率上升相关，日益受到关注，但来自印度糖尿病队列的数据有限。本研究调查了肌肉减少症和肌肉减少性肥胖的患病率及相关临床因素。
在这项横断面研究中，采用系统分层和固定配额抽样技术，从医疗营地招募了750名年龄在35 - 70岁的参与者，并分为糖尿病组（n = 250）、非糖尿病组（n = 250）和肥胖非糖尿病组（n = 250）。评估包括问卷调查、通过生物电阻抗分析估算肌肉量以及血液检测。肌肉减少症采用亚洲工作组的共识定义，肌肉减少性肥胖定义为肌肉减少症且BMI≥25 kg/m²。采用逻辑回归分析危险因素。
肌肉减少症在糖尿病患者中占60%，非糖尿病患者中占28%，非肥胖非糖尿病患者中占38%（p < 0.001）。肌肉减少性肥胖的患病率分别为40%、11%和30%（p < 0.001）。调整后，糖尿病与肌肉减少症的患病几率高2.3倍（95% CI 1.1 - 4.7）以及肌肉减少性肥胖的患病几率高2.4倍（1.1 - 5.0）相关。病程超过10年、糖尿病未得到控制、年龄大于65岁、体力活动少、高血压和血脂异常也独立增加患病几率。
印度2型糖尿病成年人肌肉减少症和肌肉减少性肥胖负担较重。早期优化糖尿病护理和改变生活方式对保持肌肉健康至关重要。
