Wan Haoxin, Xiang Jian, Mao Guocai, Pan Shu, Li Bing, Lu Yi
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Affiliated Hospital of Yangzhou University, Yangzhou 225000, China.
ACS Omega. 2024 May 29;9(23):24219-24235. doi: 10.1021/acsomega.4c02847. eCollection 2024 Jun 11.
In recent years, 3D bioprinting with various types of bioinks has been widely used in tissue engineering to fabricate human tissues and organs with appropriate biological functions. Decellularized extracellular matrix (dECM) is an excellent bioink candidate because it is enriched with a variety of bioactive proteins and bioactive factors and can provide a suitable environment for tissue repair or tissue regeneration while reducing the likelihood of severe immune rejection. In this Review, we systematically review recent advances in 3D bioprinting and decellularization technologies and comprehensively detail the latest research and applications of dECM as a bioink for tissue engineering in various systems, with the aim of providing a reference for researchers in tissue engineering to better understand the properties of dECM bioinks.
近年来，使用各种生物墨水的3D生物打印已在组织工程中广泛应用，以制造具有适当生物学功能的人体组织和器官。脱细胞细胞外基质（dECM）是一种出色的生物墨水候选材料，因为它富含多种生物活性蛋白和生物活性因子，并且可以为组织修复或组织再生提供合适的环境，同时降低严重免疫排斥反应的可能性。在本综述中，我们系统地回顾了3D生物打印和脱细胞技术的最新进展，并全面详细地介绍了dECM作为组织工程生物墨水在各种系统中的最新研究和应用，旨在为组织工程领域的研究人员提供参考，以便更好地了解dECM生物墨水的特性。
