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Monogenic gene therapy for glaucoma and optic nerve injury.

作者信息

Harada Chikako, Guo Xiaoli, Harada Takayuki

机构信息

Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

出版信息

Neural Regen Res. 2025 Mar 1;20(3):815-816. doi: 10.4103/NRR.NRR-D-24-00133. Epub 2024 May 17.

DOI:10.4103/NRR.NRR-D-24-00133

PMID:38886952

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11433919/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/847d/11433919/6f30c867860c/NRR-20-815-g001.jpg

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Effects of constitutively active K-Ras on axon regeneration after optic nerve injury.

Neurosci Lett. 2023 Mar 16;799:137124. doi: 10.1016/j.neulet.2023.137124. Epub 2023 Feb 11.

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Monogenic gene therapy for glaucoma and optic nerve injury.

作者信息

Harada Chikako, Guo Xiaoli, Harada Takayuki

机构信息

Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

出版信息

Neural Regen Res. 2025 Mar 1;20(3):815-816. doi: 10.4103/NRR.NRR-D-24-00133. Epub 2024 May 17.

DOI:10.4103/NRR.NRR-D-24-00133

PMID:38886952

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11433919/

Abstract

摘要

相似文献

Monogenic gene therapy for glaucoma and optic nerve injury.

Neural Regen Res. 2025 Mar 1;20(3):815-816. doi: 10.4103/NRR.NRR-D-24-00133. Epub 2024 May 17.

Radiation pretreatment does not protect the rat optic nerve from elevated intraocular pressure-induced injury.

Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):412-9. doi: 10.1167/iovs.14-15094.

Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Optic Nerve Crush and Experimental Glaucoma.

Int J Mol Sci. 2023 Sep 6;24(18):13719. doi: 10.3390/ijms241813719.

Astrocytes in the Optic Nerve Are Heterogeneous in Their Reactivity to Glaucomatous Injury.

Cells. 2023 Aug 23;12(17):2131. doi: 10.3390/cells12172131.

Study on the deformations of the lamina cribrosa during glaucoma.

Acta Biomater. 2017 Jun;55:340-348. doi: 10.1016/j.actbio.2017.03.028. Epub 2017 Mar 18.

Molecular mechanisms after optic nerve injury: Neurorepair strategies from a transcriptomic perspective.

Neural Regen Res. 2025 Apr 29. doi: 10.4103/NRR.NRR-D-24-00794.

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2236-43.

Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model.

Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3161-77. doi: 10.1167/iovs.06-1282.

Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma.

Invest Ophthalmol Vis Sci. 2011 Jan 25;52(1):504-18. doi: 10.1167/iovs.10-5317. Print 2011 Jan.

[Aiming for zero blindness].

Nippon Ganka Gakkai Zasshi. 2015 Mar;119(3):168-93; discussion 194.

引用本文的文献

Melatonin in Glaucoma: Integrative Mechanisms of Intraocular Pressure Control and Neuroprotection.

Biomedicines. 2025 May 16;13(5):1213. doi: 10.3390/biomedicines13051213.

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Biomedicines. 2025 Feb 5;13(2):365. doi: 10.3390/biomedicines13020365.

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Vision Res. 2025 Feb;227:108533. doi: 10.1016/j.visres.2024.108533. Epub 2024 Dec 6.

Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling.

Biochem Biophys Rep. 2024 Jul 26;39:101799. doi: 10.1016/j.bbrep.2024.101799. eCollection 2024 Sep.

本文引用的文献

Glial cells as a promising therapeutic target of glaucoma: beyond the IOP.

Front Ophthalmol (Lausanne). 2024 Jan 8;3:1310226. doi: 10.3389/fopht.2023.1310226. eCollection 2023.

A molecular switch for neuroprotective astrocyte reactivity.

Nature. 2024 Feb;626(7999):574-582. doi: 10.1038/s41586-023-06935-3. Epub 2023 Dec 12.

Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation.

Cell Death Discov. 2023 May 15;9(1):166. doi: 10.1038/s41420-023-01460-8.

Effects of constitutively active K-Ras on axon regeneration after optic nerve injury.

Neurosci Lett. 2023 Mar 16;799:137124. doi: 10.1016/j.neulet.2023.137124. Epub 2023 Feb 11.

Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors.

Mol Ther. 2023 Mar 1;31(3):810-824. doi: 10.1016/j.ymthe.2022.11.018. Epub 2022 Dec 5.

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.

Sci Adv. 2022 Nov 4;8(44):eabq1081. doi: 10.1126/sciadv.abq1081.

Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art.

Front Pharmacol. 2022 May 20;13:875662. doi: 10.3389/fphar.2022.875662. eCollection 2022.

Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery.

Sci Adv. 2021 Mar 31;7(14). doi: 10.1126/sciadv.abd2590. Print 2021 Mar.

Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning.

Br J Ophthalmol. 2019 Feb;103(2):161-166. doi: 10.1136/bjophthalmol-2018-312724. Epub 2018 Oct 26.

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.

Nature. 2011 Nov 6;480(7377):372-5. doi: 10.1038/nature10594.