Shenep J L, Stokes D C, Hughes W T
Infect Immun. 1985 Jun;48(3):607-10. doi: 10.1128/iai.48.3.607-610.1985.
The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of hydrogen peroxide, 0.23 mM) in experimentally infected rabbits. No decrease in the level of bacteremia was detected at the maximum intravenous infusion rate of hydrogen peroxide physiologically tolerated by the rabbits (2.0 mumol/h). Moreover, the addition ex vivo of greater amounts of hydrogen peroxide to human or murine blood containing E. coli resulted in no detectable antibacterial action. In contrast, ethyl hydrogen peroxide, which is not affected by catalase, was bactericidal when added ex vivo to human blood containing E. coli. These results suggest that extracellular hydrogen peroxide, whether of exogenous or endogenous origin, does not have antibacterial activity in the blood of animals having even low levels of catalase.
据报道，静脉注射过氧化氢对肺炎患者有益，并能降低实验感染小鼠的疟原虫血症。我们评估了静脉输注过氧化氢对实验感染兔体内过氧化氢敏感的大肠杆菌（过氧化氢的最低杀菌浓度为0.23 mM）的抗菌活性。在兔生理耐受的过氧化氢最大静脉输注速率（2.0 μmol/h）下，未检测到菌血症水平的降低。此外，在含有大肠杆菌的人血或鼠血中体外添加大量过氧化氢未产生可检测到的抗菌作用。相比之下，不受过氧化氢酶影响的乙基过氧化氢在体外添加到含有大肠杆菌的人血中时具有杀菌作用。这些结果表明，无论是外源性还是内源性的细胞外过氧化氢，在过氧化氢酶水平甚至很低的动物血液中都没有抗菌活性。
